JGG 1984, 11(6): 494-504 DOI:   ISSN: 1673-8527 CN: 11-5450/R           

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Cytogenetic Studies on 14 Cases wi Amenorrhea

Zhou Huangeng1, Kang Xuezhen1, Zhang Qingqing2, Chen Wenzhen3, Zhang Ruixia3,Lu Huibi3

1.Medical Genetics Laboratory,Shanghai First Medical College; 2.Department of Ob stetrics and Gynecology,Zhongshan Hospital,Shanghai First Medical College; 3.Lab oratory of Cytogenetics,Fujian Maternity and Child Health Hospital,Fuzhou


Using several cytogenetic technics,the etiology of 14 cases with amenorrhea was studied.The abonomal karyotypes were found in 11 cases (78.6% cases studied),inc luding 45,X (3 cases);45,X/46,X,i (Xq) (2 cases);45,X/46,XX/47,XXX (1 case);45,X /46,X,idic (X) (1 case);46,X,idic (X) (1 case);46,X del (X) (q24) (1 case);45,X/ 46,X,idic (X) (p 11.3) (1 case) and 46,XY (1 case).54.5% of these cases involve the structural rearrangement of X chromosome.The cytogenetic mechanism of the pa tients with amenorrhea,the possible relationship between karyotype and phenotype ,and the pattern of the replicate region in inactivated X chromosomes were discu ssed.

Received 1900-01-01 Revised 1900-01-01 Online 1984-11-10 
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