JGG 2002, 29(11): 0-952 DOI:   ISSN: 1673-8527 CN: 11-5450/R           

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Study of ABO Blood Group Secretor Type a(1,2)-FucosyItransferase Gene Polymorphism in Chinese

ZHANG Ying1,2; WANG Li1; JIA Xu-Ming1; ZHANG Duan-Yang1; XUAN Shi-Wei2; JIN Feng1

1.Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101,China 2.College of Life Science,Northeast Agriculture University,Harbin 150030 China


Secretor gene (FUT2)-encoded secretor type a(1,2)-fucosyltransferase (Se enzyme) that regulates expression and secretion of ABO (H) antigens in epithelial cell of glands and body fluids. It has the extensive polymorphism and race specificity. In the present study, we investigated the distribution of the fusion gene of the FUT2 locus in 191 Manchu individuals from Liaoning Province and 208 Mongolian individuals from Inner Mongolia, and analyzed the polymorphism of the FUT2 gene in 90 unrelated Han Chinese from Shandong Province and 90 Mongolian from Inner Mongolia,respectively. The fusion gene was not found in the two investigated ethnic groups. The frequencies of G849A nonsense mutation in Shandong Han Chinese and Mongolian of Inner Mongolia individuals were the same, 0.0055.

Keywords FUT2 gene   genetic polymorphism   Chinese population  
Received 1900-01-01 Revised 1900-01-01 Online 2002-11-10 
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