An Entropy-based Index for Fine-scale Mapping of QTL

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An Entropy-based Index for Fine-scale Mapping of QTL

Yang Xiang, Yumei Li, Zaiming Liu, Zhenqiu Sun

文章导航 > Journal of Genetics and Genomics > 2007 > 34(4): 373-380

Yang Xiang, Yumei Li, Zaiming Liu, Zhenqiu Sun. An Entropy-based Index for Fine-scale Mapping of QTL[J]. Journal of Genetics and Genomics, 2007, 34(4): 373-380. doi: 10.1016/S1673-8527(07)60040-X

Citation:

Yang Xiang, Yumei Li, Zaiming Liu, Zhenqiu Sun. An Entropy-based Index for Fine-scale Mapping of QTL[J]. Journal of Genetics and Genomics, 2007, 34(4): 373-380. doi: 10.1016/S1673-8527(07)60040-X

Yang Xiang, Yumei Li, Zaiming Liu, Zhenqiu Sun. An Entropy-based Index for Fine-scale Mapping of QTL[J]. Journal of Genetics and Genomics, 2007, 34(4): 373-380. doi: 10.1016/S1673-8527(07)60040-X

Citation:

Yang Xiang, Yumei Li, Zaiming Liu, Zhenqiu Sun. An Entropy-based Index for Fine-scale Mapping of QTL[J]. Journal of Genetics and Genomics, 2007, 34(4): 373-380. doi: 10.1016/S1673-8527(07)60040-X

doi: 10.1016/S1673-8527(07)60040-X

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出版历程
- 收稿日期: 2006-06-16
- 录用日期: 2006-08-04
- 网络出版日期: 2007-05-09
- 刊出日期: 2007-04-20

An Entropy-based Index for Fine-scale Mapping of QTL

Yang Xiang^{a, c},
Yumei Li^{b, c
, ,},
Zaiming Liu^a,
Zhenqiu Sun^b

a.
College of Mathematics, Central South University, Changsha 410081, China
b.
School of Public Health, Central South University, Changsha 410078, China
c.
Mathematics Department of Huaihua College, Huaihua 418000, China

More Information

Corresponding author: E-mail address: lymmail@126.com (Yumei Li)

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Abstract: By comparing the entropy and conditional entropy in a marker, an entropy-based index for fine-scale linkage-disequilibrium gene mapping is presented using high-density marker maps in extreme samples for quantitative trait. The entropy-based index is the function of LD between the marker and the trait locus and does not depend on marker allele frequencies across the loci. It is parallel to Hardy-Weinberg disequilibrium (HWD) measure for QTL fine mapping, but its power of fine mapping QTL is higher than that of HWD measure. Through simulations, the fine mapping performance of this entropy-based index is investigated extensively under various genetic parameters. The results show that the indices presented here are both robust and powerful.
- entropy /
- entropy-based Index /
- QTL /
- fine mapping

参考文献(7)

[1]	Jiang, R, Dong, et al. Fine-scale mapping using Hardy-Weinberg disequilibrium Ann Hum Genet, 65 (2001),pp. 207-219
[2]	Deng, HW, Chen, et al. QTL fine mapping by measuring and test for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations Am J Hum Genet, 66 (2000),pp. 1027-1045
[3]	Deng, HW, Li, et al. Robust indices of Hardy-Weinberg disequilibrium for QTL fine mapping Hum Hered, 56 (2003),pp. 160-165
[4]	Zhao, JY, Boerwinkle, et al. An entropy-based statistic for genomewide association studies Am J Hum Genet, 77 (2005),pp. 27-40
[5]	Shannon, CE A mathematical theory of communication MD Comput, 14 (1997),pp. 306-317
[6]	Hampe, J, Schreiber, et al. Entropy-based SNP selection for genetic association studies Hum Genet, 114 (2003),pp. 36-43
[7]	Hartl, DL

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