Genetic Polymorphism of Mitochondrial DNA in Dong, Gelao, Tujia, and Yi Ethnic Populations from Guizhou, China

a.
Department of Pathophysiology, Guangdong Medical College, Zhanjiang 524023, China
b.
Institute of Medicine Science, Guiyang Medical College, Guiyang 550004, China
c.
The People's Hospital of Tianzhu County, Tianzhu 556700, China
d.
The People's Hospital of Hezhang County, Hezhang 553200, China
e.
The People's Hospital of Wuchuan County, Wuchuan 564300, China

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Corresponding author: E-mail address: zhongfuguang@hotmail.com (Fuguang Zhong)

摘要

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Abstract: To reveal the genetic structures and relationships of the four ethnic populations from the maternal inheritance and explore the origins and migrations of nationalities, the genetic polymorphism of mtDNA in Dong, Gelao, Tujia, and Yi populations from Guizhou was studied by direct sequencing of hypervariable segment I(HVS I) and PCR-RFLP of coding region. Thirty-seven (sub-) haplogroups were identified in the classification tree of mtDNA haplogroups. Haplogroup distributions and principal component (PC) analysis showed that the Dong has high frequencies of south-prevalent haplogroups, which indicates that it is a typically southern population. The Yi harbors high frequencies of the south-prevalent and northern-prevalent haplogroups, which demonstrates that it inherits the maternal characteristics from both southern and northern populations. The Yi and Gelao cluster together, the reason for which might be that their ancestries frequently underwent gene exchanges and mixtures.
- ethnic populations in Guizhou /
- mitochondrial DNA /
- polymorphism

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参考文献(20)

[1]	S, Anderson, AT, et al. Sequence and organization of the human mitochondrial genome Nature, 290 (1981),pp. 457-465
[2]	DC, Wallace, MD, et al. Mitochondrial DNA variation in human evolution and disease Gene, 238 (1999),pp. 211-230
[3]	RL, Cann, M, et al. Mitochondrial DNA and human evolution Nature, 325 (1987),pp. 31-36
[4]	T, Kivisild, HV, et al. The emerging limbs and twigs of the East Asian mtDNA tree Mol Biol Evol, 19 (2002),pp. 1737-1751
[5]	YG, Yao, QP, et al. Phylogeographic differentiation of mitochondrial DNA in Han Chinese Am J Hum Genet, 70 (2002),pp. 635-651
[6]	W, Wang, LM, et al. An improved method for isolation of animal mitochondrial DNA Zool Res, 14 (1993),pp. 197-198
[7]	YG, Yao, XM, et al. Gene admixture in the silk road region of China: Evidence from mtDNA and melanocortin 1 receptor polymorphism Genes Genet Syst, 75 (2000),pp. 173-178
[8]	V, Macaulay, M, et al. The emerging tree of West Eurasian mtDNAs: A synthesis of control-region sequences and RFLPs Am J Hum Genet, 64 (1999),pp. 232-249
[9]	A, Salas, M, et al. The making of the African mtDNA landscape Am J Hum Genet, 71 (2002),pp. 1082-1111
[10]	YG, Yao, YP, et al. Phylogeographic analysis of mtDNA variation in four ethnic populations from Yunnan Province: new data and a reappraisal J Hum Genet, 47 (2002),pp. 311-318
[11]	YG, Yao, QP, et al. Different matrilineal contributions to genetic structure of ethnic groups in the Silk Road Region in China Mol Biol Evol, 21 (2004),pp. 2265-2280
[12]	RM, Andrews, I, et al. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA Nat Genet, 23 (1999),p. 147
[13]	A, Torroni, K, et al. Classification of European mtDNAs from an analysis of three European populations Genetics, 144 (1996),pp. 1835-1850
[14]	A, Torroni, HJ, et al. mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe Am J Hum Genet, 62 (1998),pp. 1137-1152
[15]	HJ, Bandelt, V, et al. Median networks: Speedy construction and greedy reduction, one simulation, and two case studies from human mtDNA Mol Phylogenet Evol, 16 (2000),pp. 8-28
[16]	A, Torroni, M, et al. mtDNA haplogroups and frequency patterns in Europe Am J Hum Genet, 66 (2000),pp. 1173-1177
[17]	PL, Zhao On the source of Tujia nationality in Guizhou province Journal of Guiyang Teacher's College, 3 (2003),pp. 1-6
[18]	RF, Du The study of human popoulation genetics in Chinese populations Bull Biol, 32 (1997),pp. 9-12
[19]	L, Gao, YL, et al. Genetic polymorphism of mitochondrial DNA in coding region in 16 ethnic populations of Yunnan Acta Genet Sin, 32 (2005),pp. 118-123
[20]	SZ, Hou, JZ, et al.