New players in the regulation of ecdysone biosynthesis

a.
Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
b.
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA

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Corresponding author: E-mail address: xhuang@genetics.ac.cn (Xun Huang); E-mail address: lgilbert@bio.unc.edu (Lawrence I. Gilbert)

摘要

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Abstract: Insect ecdysone steroid hormone regulates major developmental transitions, such as molting and metamorphosis. The production of ecdysone correlates well with the timing of these transitions. Finding out how the ecdysone biosynthesis is regulated is crucial to fully understand these sophisticated developmental switches. Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking.
- ecdysone /
- cholesterol /
- PTTH /
- P450

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参考文献(51)

[1]	Agui, N., Granger, N.A., Gilbert, L.I. et al. Proc. Natl. Acad. Sci. USA, 76 (1979),pp. 5694-5698
[2]	Altmann, S.W., , Zhu, L.J., Yao, X. et al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption Science, 303 (2004),pp. 1201-1204
[3]	Asami, T., Nakano, T., Fujioka, S. Plant brassinosteroid hormones Vitam. Horm., 72 (2005),pp. 479-504
[4]	Beckstead, R.B., Thummel, C.S. Indicted: worms caught using steroids Cell, 124 (2006),pp. 1137-1140
[5]	Caldwell, P.E., Walkiewicz, M., Stern, M. Curr. Biol., 15 (2005),pp. 1785-1795
[6]	Carstea, E.D., Morris, J.A., Coleman, K.G. et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis Science, 277 (1997),pp. 228-231
[7]	Chávez, V.M., Marqués, G., Delbecque, J.P. et al. Development, 127 (2000),pp. 4115-4126
[8]	Christenson, L.K., Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterol Biochim. Biophys. Acta, 1529 (2000),pp. 175-187
[9]	Clark, A.J., Block, K. The absence of sterol synthesis in insects J. Biol. Chem., 234 (1959),pp. 2578-2582
[10]	Fellner, S.K., Rybczynski, R., Gilbert, L.I. Insect Biochem. Mol. Biol., 35 (2005),pp. 263-275
[11]	Fluegel, M.L., Parker, T.J., Pallanck, L.J. Genetics, 172 (2006),pp. 185-196
[12]	Goldstein, J.L., DeBose-Boyd, R.A., Brown, M.S. Protein sensors for membrane sterols Cell, 124 (2006),pp. 35-46
[13]	Griffin, L.D., Gong, W., Verot, L. et al. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone Nat. Med., 10 (2004),pp. 704-711
[14]	Henrich, V.C., Pak, M.D., Gilbert, L.I. J. Comp. Physiol. [B], 157 (1987),pp. 543-549
[15]	Henrich, V.C., Tucker, R.L., Maroni, G. et al. Dev. Biol., 120 (1987),pp. 50-55
[16]	Hosie, A.M., Wilkins, M.E., da Silva, H.M. et al. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites Nature, 444 (2006),pp. 486-489
[17]	Huang, X., Suyama, K., Buchanan, J. et al. Development, 132 (2005),pp. 5115-5124
[18]	Huang, X., Warrent, J.T., Buchanan, J. et al. Development, 134 (2007),pp. 3733-3742
[19]	Ishizaki, H., Suzuki, A. Int. J. Dev. Biol., 38 (1994),pp. 301-310
[20]	Jürgens, G., Wieschaus, E., Nüsslein-Volhard, C. et al. Roux's Arch. Dev. Biol., 193 (1984),pp. 282-295
[21]	Kappler, C., Kabbouh, M., Hetru, C. et al. J. Steroid Biochem., 31 (1988),pp. 891-898
[22]	Kataoka, H., Nagasawa, H., Isogai, A. et al. Agric. Biol. Chem., 55 (1991),pp. 73-86
[23]	Kim, A.J., Cha, G.H., Kim, K. et al. Proc. Natl. Acad. Sci. USA, 94 (1997),pp. 1130-1135
[24]	Kopeć, S. Studies on the necessity of the brain for the inception of insect metamorphosis Biol. Bull., 42 (1922),pp. 323-342
[25]	Lan, Q., Massey, R.J. Subcellular localization of the mosquito sterol carrier protein-2 and sterol carrier protein-x J. Lipid Res., 45 (2004),pp. 1468-1474
[26]	Liscum, L., Faust, J.R. Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts J. Biol. Chem., 262 (1987),pp. 17002-17008
[27]	McBrayer, Z., Ono, H., Shimell, M. et al. Development Cell,, 13 (2007),pp. 857-871
[28]	Namiki, T., Niwa, R., Sakudoh, T. et al. Cytochrome P450 CYP307A1/Spook: a regulator for ecdysone synthesis in insects Biochem. Biophys. Res. Commun., 337 (2005),pp. 367-374
[29]	Neubueser, D., Warrent, J.T., Gilbert, L.I. et al. Dev. Biol., 280 (2005),pp. 362-372
[30]	Niwa, R., Matsuda, T., Yoshiyama, T. et al. J. Biol. Chem., 279 (2004),pp. 35942-35949
[31]	Nüsslein-Volhard, C., Wieschaus, E., Kluding, H. Roux's Arch. Dev. Biol., 183 (1984),pp. 267-282
[32]	Ono, H., Rewitz, K.F., Shinoda, T. et al. Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera Dev. Biol., 298 (2006),pp. 555-570
[33]	Parkin, C.A., Burnet, B. J. Insect. Physiol., 32 (1986),pp. 463-471
[34]	Parvy, J.P., Blais, C., Bernard, F. et al. Dev. Biol., 282 (2005),pp. 84-94
[35]	Petryk, A., Warren, J.T., Marqués, G. et al. Proc. Natl. Acad. Sci. USA, 100 (2003),pp. 13773-13778
[36]	Rewitz, K.F., Rybczynski, R., Warrent, J.T. et al. The Halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormone Biochem. Soc. Trans., 34 (2006),pp. 1256-1260
[37]	Riddiford, L.M., Cherbas, P., Truman, J.W. Ecdysone receptors and their biological actions Vitam. Horm., 60 (2000),pp. 1-73
[38]	Rodenburg, K.W., van der Horst, D.J. Lipoprotein-mediated lipid transport in insects: analogy to the mammalian lipid carrier system and novel concepts for the functioning of LDL receptor family members Biochim. Biophys. Acta, 1736 (2005),pp. 10-29
[39]	Roth, G.E., Gierl, M.S., Vollborn, L. et al. Proc. Natl. Acad. Sci. USA, 101 (2004),pp. 1601-1606
[40]	Rottiers, V.D., Gerisch, M.B., Cummins, C. et al. Dev. Cell, 10 (2006),pp. 473-482
[41]	Smith, W.A., Gilbert, L.I., Bollenbacher, W.E. Calcium-cyclic AMP interactions in prothoracicotropic hormone stimulation of ecdysone synthesis Mol. Cell. Endocrinol., 39 (1985),pp. 71-78
[42]	Song, Q., Gilbert, L.I. S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: a role for S6 kinase Dev. Genet., 15 (1994),pp. 332-338
[43]	Stolowich, N.J., Petrescu, A.D., Huang, H. et al. Sterol carrier protein-2: structure reveals function Cell Mol. Life Sci., 59 (2002),pp. 193-212
[44]	Vedeckis, W.V., Bollenbacher, W.E., Gilbert, L.I. Insect prothoracic glands: a role for cyclic AMP in the stimulation of alpha-ecdysone secretion Mol. Cell. Endocrinol., 5 (1976),pp. 81-88
[45]	Voght, S.P., Fluegel, M.L., Andrews, L.A. et al. Cell Metab., 5 (2007),pp. 195-205
[46]	Warren, J.T., Petryk, A., Marques, G. et al. Proc. Natl. Acad. Sci. USA, 99 (2002),pp. 11043-11048
[47]	Warren, J.T., Petryk, A., Marqués, G. et al. Insect Biochem. Mol. Biol., 34 (2004),pp. 991-1010
[48]	Warrent, J.T., Wismar, J., Subrahmanyam, B. et al. Mol. Cell Endocrinol., 181 (2001),pp. 1-14
[49]	Wieschaus, E., Nüsslein-Volhard, C., Jürgens, G. Roux's Arch. Dev. Biol., 193 (1984),pp. 296-307
[50]	Wismar, J., Habtemichael, N., Warren, J.T. et al. Dev. Biol., 226 (2000),pp. 1-17
[51]	Yoshiyama, T., Namiki, T., Mita, K. et al. Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth Development, 133 (2006),pp. 2565-2574