Cytoplasmic Poly(A) Binding Protein 4 Is Highly Expressed in Human Colorectal Cancer and Correlates with Better Prognosis

Dan Liu^{a, b},
Bin Yin^c,
Qiang Wang^d,
Wenyi Ju^c,
Yuanjia Chen^a,
Huizhong Qiu^e,
Ji Li^f,
Xiaozhong Peng^{c
, ,},
Chongmei Lu^{a
, ,}

a.
Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
b.
Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
c.
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
d.
Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
e.
Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
f.
Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

More Information

Corresponding author: E-mail address: pengxiaozhong@pumc.edu.cn (Xiaozhong Peng); E-mail address: pekingunion@yahoo.cn (Chongmei Lu)

摘要

- /
- /
- /
Abstract: Cytoplasmic poly(A) binding protein 4 (PABPC4) is an RNA-processing protein that plays an important role in the regulation of gene expression. The aim of this study was to investigate the expression pattern and identify the potential clinical significance of PABPC4 in colorectal cancer. Immunohistochemical analysis revealed that 26.7% (27/101 patients) of primary colorectal tumors and 60.5% (23/38 patients) of corresponding adjacent, normal tissues showed high cytoplasmic expression of PABPC4, whereas expression was absent in 98% (43/44 patients) of distant, normal tissues. Using Kaplan–Meier analysis, we observed that the expression of PABPC4 was significantly correlated with disease-free survival and overall survival in patients with stage II and stage III colorectal cancer (P=0.022 and P=0.020, respectively). PABPC4 expression was positively associated with survival outcome, and may have predictive value in the prognosis of patients with colorectal cancer. Taken together, our findings indicate that PABPC4 may play a role in the pathogenesis of colorectal cancer.
- Colorectal cancer /
- PABPC4 /
- Poly(A) tail /
- Prognosis

HTML全文

参考文献(12)

[1]	Decker, C.J., Parker, R. mRNA decay enzymes: decappers conserved between yeast and mammals Proc. Natl. Acad. Sci. USA, 99 (2002),pp. 12512-12514
[2]	Gorgoni, B., Richardson, W.A., Burgess, H.M. et al. Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development Proc. Natl. Acad. Sci. USA, 108 (2011),pp. 7844-7849
[3]	Graff, J.R., Konicek, B.W., Lynch, R.L. et al. eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival Cancer Res., 69 (2009),pp. 3866-3873
[4]	Houng, A.K., Maggini, L., Clement, C.Y. et al. Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motif that is expressed by activated platelets Europ. J. Biochem., 243 (1997),pp. 209-218
[5]	Jemal, A., Siegel, R., Xu, J. et al. Cancer statistics, 2010 CA Cancer J. Clin., 60 (2010),pp. 277-300
[6]	Katzenellenbogen, R.A., Vliet-Gregg, P., Xu, M. et al. Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes J. Virol., 84 (2010),pp. 12934-12944
[7]	Loconte, N.K., Williamson, A., Gayle, A. et al. Increasing disparity in colorectal cancer incidence and mortality among African Americans and whites: a state's experience J. Gastrointest. Oncol., 2 (2011),pp. 85-92
[8]	Miyata, Y., Watanabe, S., Matsuo, T. et al. Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer Prostate, 72 (2012),pp. 201-208
[9]	Okochi, K., Suzuki, T., Inoue, J. et al. Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control Genes Cells., 10 (2005),pp. 151-163
[10]	Shahbazian, D., Parsyan, A., Petroulakis, E. et al. eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways Cell Cycle, 9 (2010),pp. 4106-4109
[11]	Villalba, A., Coll, O., Gebauer, F. Cytoplasmic polyadenylation and translational control Curr. Opin. Genet. Dev., 21 (2011),pp. 452-457
[12]	Yang, H., Duckett, C.S., Lindsten, T. iPABP, an inducible poly(A)-binding protein detected in activated human T cells Mol. Cell. Biol., 15 (1995),pp. 6770-6776

施引文献

资源附件(0)

访问统计

点击查看大图

计量

文章访问数: 75
HTML全文浏览量: 29
PDF下载量: 1
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

doi: 10.1016/j.jgg.2012.05.007

计量

Cytoplasmic Poly(A) Binding Protein 4 Is Highly Expressed in Human Colorectal Cancer and Correlates with Better Prognosis

Corresponding author: E-mail address: pengxiaozhong@pumc.edu.cn (Xiaozhong Peng); E-mail address: pekingunion@yahoo.cn (Chongmei Lu)

计量

目录

留言板

doi: 10.1016/j.jgg.2012.05.007

计量

出版历程

Cytoplasmic Poly(A) Binding Protein 4 Is Highly Expressed in Human Colorectal Cancer and Correlates with Better Prognosis

Corresponding author: E-mail address: pengxiaozhong@pumc.edu.cn (Xiaozhong Peng); E-mail address: pekingunion@yahoo.cn (Chongmei Lu)

计量

出版历程

目录