Evolutionary and Functional Analysis of the Key Pluripotency Factor Oct4 and Its Family Proteins

Xinmin Zhang^{a, #},
Yuzhen Ma^{e, #},
Xiuying Liu^{b, d},
Qi Zhou^{c
, ,},
Xiu-Jie Wang^{b
, ,}

a.
Computer & Information Engineering College, Inner Mongolia Normal University, Inner Mongolia, Hohhot 010022, China
b.
State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
c.
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
d.
University of Chinese Academy of Sciences, Beijing 100101, China
e.
Centre of Reproductive Medicine, Inner Mongolia Hospital, Inner Mongolia, Hohhot 010017, China

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Corresponding author: E-mail address: qzhou@ioz.ac.cn (Qi Zhou); E-mail address: xjwang@genetics.ac.cn (Xiu-Jie Wang)

These authors contributed equally to this work.

摘要

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Abstract: Oct4 is one of the key pluripotent factors essential for embryonic stem cells and induced pluripotent stem (iPS) cells. Oct4 belongs to the POU domain family, which contains multiples genes with various important functions. Although the function of Oct4 has been extensively studied, detailed comparison of Oct4 with other POU family genes and their evolutionary analysis are still lacking. Here, we systematically identified POU family genes from lower to higher animal species. We observed an expansion of POU family genes in vertebrates, with an additional increment in mammalian genomes. We analyzed the phylogenetic relationship, tissue specific expression profiles and regulatory networks of POU family genes of the human genome, and predicted the putative binding microRNAs of human POU family genes. These results provide the first comprehensive evolutionary and comparative analysis of POU family genes, which will help to better understand the relationships among POU family genes and shed light on their future functional studies.
- Oct4 /
- Induced pluripotent stem cell /
- POU family /
- MicroRNA /
- Evolutionary analysis
These authors contributed equally to this work.
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doi: 10.1016/j.jgg.2013.04.011

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Evolutionary and Functional Analysis of the Key Pluripotency Factor Oct4 and Its Family Proteins

Corresponding author: E-mail address: qzhou@ioz.ac.cn (Qi Zhou); E-mail address: xjwang@genetics.ac.cn (Xiu-Jie Wang)

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doi: 10.1016/j.jgg.2013.04.011

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Evolutionary and Functional Analysis of the Key Pluripotency Factor Oct4 and Its Family Proteins

Corresponding author: E-mail address: qzhou@ioz.ac.cn (Qi Zhou); E-mail address: xjwang@genetics.ac.cn (Xiu-Jie Wang)

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