Sperm Mitochondria in Reproduction: Good or Bad and Where Do They Go?

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Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China
b.
Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
c.
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

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Corresponding author: E-mail address: sunqy@ioz.ac.cn (Qing-Yuan Sun)

摘要

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Abstract: The mitochondrion is the major energy provider to power sperm motility. In mammals, aside from the nuclear genome, mitochondrial DNA (mtDNA) also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides. However, the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial. The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted. However, this may be not true for several mammalian species, including mice and humans. Here, we review the sperm mitochondria and their mtDNA in sperm functions, and the mechanisms of maternal mitochondrial inheritance in mammals.
- Mitochondrial DNA /
- Maternal inheritance /
- Paternal inheritance /
- Autophagy /
- Oxidative phosphorylation /
- Ubiquitination

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参考文献(93)

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