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Expression of Epitope-Tagged SYN3 Cohesin Proteins Can Disrupt Meiosis in Arabidopsis

Li Yuan,  Xiaohui Yang,  Dirk Auman,  Christopher A. Makaroff

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文章导航 > Journal of Genetics and Genomics  > 2014 >  41(3): 153-164
Li Yuan, Xiaohui Yang, Dirk Auman, Christopher A. Makaroff. Expression of Epitope-Tagged SYN3 Cohesin Proteins Can Disrupt Meiosis in Arabidopsis[J]. Journal of Genetics and Genomics, 2014, 41(3): 153-164. doi: 10.1016/j.jgg.2013.11.006
Citation: Li Yuan, Xiaohui Yang, Dirk Auman, Christopher A. Makaroff. Expression of Epitope-Tagged SYN3 Cohesin Proteins Can Disrupt Meiosis in Arabidopsis[J]. Journal of Genetics and Genomics, 2014, 41(3): 153-164. doi: 10.1016/j.jgg.2013.11.006
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doi: 10.1016/j.jgg.2013.11.006
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Expression of Epitope-Tagged SYN3 Cohesin Proteins Can Disrupt Meiosis in Arabidopsis

  • Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA

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    Abstract: α-kleisins are core components of meiotic and mitotic cohesin complexes. Arabidopsis contains genes encoding four α-kleisins. SYN1, a REC8 ortholog, is essential for meiosis, while SYN2 and SYN4 appear to be SCC1 orthologs and function in mitosis. SYN3 is enriched in the nucleolus of meiotic and mitotic cells and is essential for megagametogenesis. It was recently shown that expression of SYN3-RNAi constructs in buds cause changes in meiotic gene expression that result in meiotic alterations. In this report we show that expression of SYN3 from the 35S promoter with either a c-terminal Myc or FAST tag causes a reduction in SYN1 mRNA levels that results in alterations in sister chromatid cohesion, homologous chromosome synapsis and synaptonemal complex formation during both male and female meiosis.
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出版历程
  • 收稿日期:  2013-07-24
  • 录用日期:  2013-11-26
  • 修回日期:  2013-11-23
  • 网络出版日期:  2013-12-13
  • 刊出日期:  2014-03-20

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