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Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion

Jolene S.Y. Tan,  Colin J.P. Seow,  Vera J. Goh,  David L. Silver

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文章导航 > Journal of Genetics and Genomics  > 2014 >  41(5): 251-259
Jolene S.Y. Tan, Colin J.P. Seow, Vera J. Goh, David L. Silver. Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion[J]. Journal of Genetics and Genomics, 2014, 41(5): 251-259. doi: 10.1016/j.jgg.2014.03.003
Citation: Jolene S.Y. Tan, Colin J.P. Seow, Vera J. Goh, David L. Silver. Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion[J]. Journal of Genetics and Genomics, 2014, 41(5): 251-259. doi: 10.1016/j.jgg.2014.03.003
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doi: 10.1016/j.jgg.2014.03.003
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Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion

  • Signature Research Program in Cardiovascular & Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore

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    Abstract: Lipid droplets (LDs) were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation, expansion, and morphology. The related proteins are summarized such as the fat-specific protein (Fsp27), fat storage-inducing transmembrane (FIT) proteins, seipin and ADP-ribosylation factor 1-coat protein complex I (Arf-COPI). Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved.
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    • 参考文献(81)
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出版历程
  • 收稿日期:  2013-10-25
  • 录用日期:  2014-03-05
  • 修回日期:  2014-03-03
  • 网络出版日期:  2014-03-19
  • 刊出日期:  2014-05-20

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