Identification of EGF as an Important Regulator for Promoting CYP3A4 Expression in Human Embryonic Stem Cell-Derived Hepatocytes Using TALEN-Based Gene Targeting

Ming Yin^a,
Huan Yang^b,
Xiaohua Su^b,
Ziyi Li^a,
Zhanpeng Yue^a,
Xueming Zhang^a,
Da Sun^b,
Yan Shi^{b
, ,},
Dexue Li^{a, c
, ,}

a.
College of Veterinary Medicine, Jilin University, Changchun 130062, China
b.
Shenzhen Stem Cell Engineering Laboratory, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China
c.
Academy of Military Medical Sciences, Beijing 100871, China

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Corresponding author: E-mail address: shiyan@pkusz.edu.cn (Yan Shi); E-mail address: lidx@bmi.ac.cn (Dexue Li)

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[2]	Borowiak, M., Garratt, A.N., Wustefeld, T. et al. Met provides essential signals for liver regeneration Proc. Natl. Acad. Sci. USA, 101 (2004),pp. 10608-10613
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[5]	de Sa Silva, F., Almeida, P.N., Rettore, J.V. et al. Toward personalized cell therapies by using stem cells: seven relevant topics for safety and success in stem cell therapy J. Biomed. Biotechnol., 2012 (2012)
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[10]	Hockemeyer, D., Wang, H., Kiani, S. et al. Genetic engineering of human pluripotent cells using TALE nucleases Nat. Biotechnol., 29 (2011),pp. 731-734
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[12]	Sahi, J., Grepper, S., Smith, C. Hepatocytes as a tool in drug metabolism, transport and safety evaluations in drug discovery Curr. Drug Discov. Technol., 7 (2010),pp. 188-198
[13]	Shifley, E.T., Kenny, A.P., Rankin, S.A. et al. BMC Dev. Biol., 12 (2012),p. 27
[14]	Tong, C., Huang, G., Ashton, C. et al. Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs J. Genet. Genomics, 39 (2012),pp. 275-280
[15]	Tsai, S.M., Liu, D.W., Wang, W.P. Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish Transgenic Res., 22 (2013),pp. 301-314
[16]	Zanger, U.M., Schwab, M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation Pharmacol. Ther., 138 (2013),pp. 103-141
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doi: 10.1016/j.jgg.2014.03.008

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Identification of EGF as an Important Regulator for Promoting CYP3A4 Expression in Human Embryonic Stem Cell-Derived Hepatocytes Using TALEN-Based Gene Targeting

Corresponding author: E-mail address: shiyan@pkusz.edu.cn (Yan Shi); E-mail address: lidx@bmi.ac.cn (Dexue Li)

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doi: 10.1016/j.jgg.2014.03.008

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Identification of EGF as an Important Regulator for Promoting CYP3A4 Expression in Human Embryonic Stem Cell-Derived Hepatocytes Using TALEN-Based Gene Targeting

Corresponding author: E-mail address: shiyan@pkusz.edu.cn (Yan Shi); E-mail address: lidx@bmi.ac.cn (Dexue Li)

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