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A Matrilineal Genetic Legacy from the Last Glacial Maximum Confers Susceptibility to Schizophrenia in Han Chinese

Wen Zhang,  Jinsong Tang,  A-Mei Zhang,  Min-Sheng Peng,  Hai-Bing Xie,  Liwen Tan,  Lin Xu,  Ya-Ping Zhang,  Xiaogang Chen,  Yong-Gang Yao

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文章导航 > Journal of Genetics and Genomics  > 2014 >  41(7): 397-407
Wen Zhang, Jinsong Tang, A-Mei Zhang, Min-Sheng Peng, Hai-Bing Xie, Liwen Tan, Lin Xu, Ya-Ping Zhang, Xiaogang Chen, Yong-Gang Yao. A Matrilineal Genetic Legacy from the Last Glacial Maximum Confers Susceptibility to Schizophrenia in Han Chinese[J]. Journal of Genetics and Genomics, 2014, 41(7): 397-407. doi: 10.1016/j.jgg.2014.05.004
Citation: Wen Zhang, Jinsong Tang, A-Mei Zhang, Min-Sheng Peng, Hai-Bing Xie, Liwen Tan, Lin Xu, Ya-Ping Zhang, Xiaogang Chen, Yong-Gang Yao. A Matrilineal Genetic Legacy from the Last Glacial Maximum Confers Susceptibility to Schizophrenia in Han Chinese[J]. Journal of Genetics and Genomics, 2014, 41(7): 397-407. doi: 10.1016/j.jgg.2014.05.004
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doi: 10.1016/j.jgg.2014.05.004
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A Matrilineal Genetic Legacy from the Last Glacial Maximum Confers Susceptibility to Schizophrenia in Han Chinese

  • a.

    Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

  • b.

    The Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha 410011, China

  • c.

    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

  • d.

    National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, China

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    Abstract: Mitochondrial dysfunction has been widely reported in schizophrenia patients. To dissect the matrilineal structure of Han Chinese with or without schizophrenia and to decipher the maternal influence and evolutionary history of schizophrenia, a total of 1212 schizophrenia patients and 1005 matched healthy controls, all of Han Chinese origin, were recruited in Hunan Province, China. We classified haplogroup for each individual based on mitochondrial DNA (mtDNA) sequence variations and compared the haplogroup distribution pattern between cases and controls. Haplogroup B5a presented a higher frequency in cases than in controls (P = 0.02, OR = 1.67, 95% CI = [1.09, 2.56]), and this result could be confirmed by permutation analysis. Age estimation of haplogroup B5a in cases revealed a much younger age than that of controls, which was coincident with the Northern Hemisphere deglaciation at the end of the Last Glacial Maximum. Analysis of complete mtDNA in five patients belonging to haplogroup B5a showed that this background effect might be caused by haplogroup-defining variants m.8584G>A and m.10398A>G. Our results showed that matrilineal risk factor for schizophrenia had an ancient origin and might acquire a predisposing effect on schizophrenia due to the environment change and/or orchestration with other nuclear genetic factors appeared recently in human evolutionary history.
    These authors contributed equally to this work.
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  • 收稿日期:  2014-02-28
  • 录用日期:  2014-05-21
  • 修回日期:  2014-05-16
  • 网络出版日期:  2014-06-02
  • 刊出日期:  2014-07-20

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