Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis: A Systematic Review

Changbing Shen^{a, b, c},
Jing Gao^d,
Xianyong Yin^{a, b, c},
Yujun Sheng^{a, b, c},
Liangdan Sun^{a, b, c},
Yong Cui^{a, b, c},
Xuejun Zhang^{a, b, c, d
, ,}

a.
Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China
b.
The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China
c.
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China
d.
Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, China

More Information

Corresponding author: E-mail address: ayzxj@vip.sina.com (Xuejun Zhang)

摘要

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Abstract: Psoriasis (Ps) and psoriatic arthritis (PsA) are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop (LCE) gene cluster, especially the cluster 3 (LCE3) genes. It is noteworthy that the deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future.
- Psoriasis /
- Psoriatic arthritis /
- Systematic review

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参考文献(46)

[1]	Austin, H.R., Hoss, E., Batie, S.F. et al. Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin Biochem. Biophys. Res. Commun., 443 (2014),pp. 1275-1279
[2]	Bassaganyas, L., Riveira-Munoz, E., Garcia-Aragones, M. et al. BMC Genomics, 14 (2013),p. 261
[3]	Bergboer, J.G., Zeeuwen, P.L., Irvine, A.D. et al. Deletion of late cornified envelope 3B and 3C genes is not associated with atopic dermatitis J. Invest. Dermatol., 130 (2010),pp. 2057-2061
[4]	Bergboer, J.G., Tjabringa, G.S., Kamsteeg, M. et al. Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups Am. J. Pathol., 178 (2011),pp. 1470-1477
[5]	Bergboer, J.G., Oostveen, A.M., de Jager, M.E. et al. Br. J. Dermatol., 167 (2012),pp. 922-925
[6]	Bergboer, J.G., Oostveen, A.M., de Jager, M.E. et al. J. Invest. Dermatol., 132 (2012),pp. 475-476
[7]	Bergboer, J.G., Umićević-Mirkov, M., Fransen, J. et al. PLoS One, 7 (2012),p. e32045
[8]	Bergboer, J.G., Zeeuwen, P.L., Schalkwijk, J. Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation J. Invest. Dermatol., 132 (2012),pp. 2320-2331
[9]	Bowes, J., Flynn, E., Ho, P. et al. Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis Ann. Rheum. Dis., 69 (2010),pp. 2199-2203
[10]	Capon, F., Semprini, S., Dallapiccola, B. et al. Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21 Am. J. Hum. Genet., 65 (1999),pp. 1798-1800
[11]	Capon, F., Semprini, S., Chimenti, S. et al. Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21 J. Invest. Dermatol., 116 (2001),pp. 728-730
[12]	Chandran, V. The genetics of psoriasis and psoriatic arthritis Clin. Rev. Allergy Immunol., 44 (2013),pp. 149-156
[13]	Chen, H., Poon, A., Yeung, C. et al. A genetic risk score combining ten psoriasis risk loci improves disease prediction PLoS One, 6 (2011),p. e19454
[14]	Chiraz, B.S., Myriam, A., Ines, Z. et al. Mol. Biol. Rep., 41 (2014),pp. 41411-44146
[15]	Coin, L.J., Cao, D., Ren, J. et al. An exome sequencing pipeline for identifying and genotyping common CNVs associated with disease with application to psoriasis Bioinformatics, 28 (2012),pp. i370-i374
[16]	Coto, E., Santos-Juanes, J., Coto-Segura, P. et al. BMC Med. Genet., 11 (2010),p. 45
[17]	Coto, E., Santos-Juanes, J., Coto-Segura, P. et al. New psoriasis susceptibility genes: momentum for skin-barrier disruption J. Invest. Dermatol., 131 (2011),pp. 1003-1005
[18]	de Cid, R., Riveira-Munoz, E., Zeeuwen, P.L. et al. Nat. Genet., 41 (2009),pp. 211-215
[19]	de Guzman Strong, C., Conlan, S., Deming, C.B. et al. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis Hum. Mol. Genet., 19 (2010),pp. 1453-1460
[20]	de Koning, H.D., van den Bogaard, E.H., Bergboer, J.G. et al. Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair Br. J. Dermatol., 166 (2012),pp. 1245-1254
[21]	Docampo, E., Rabionet, R., Riveira-Muñoz, E. et al. Arthritis Rheum., 62 (2010),pp. 1246-1251
[22]	Docampo, E., Giardina, E., Riveira-Muñoz, E. et al. Arthritis Rheum., 63 (2011),pp. 1860-1865
[23]	Duffin, K.C., Chandran, V., Gladman, D.D. et al. Genetics of psoriasis and psoriatic arthritis: update and future direction J. Rheumatol., 35 (2008),pp. 1449-1453
[24]	Elias, P.M. The skin barrier as an innate immune element Semin. Immunopathol., 29 (2007),pp. 3-14
[25]	Eriksson, N., Macpherson, J.M., Tung, J.Y. et al. Web-based, participant-driven studies yield novel genetic associations for common traits PLoS Genet., 6 (2010),p. 1000993
[26]	Gudjonsson, J.E., Johnston, A. Current understanding of the genetic basis of psoriasis Expert Rev. Clin. Immunol., 5 (2009),pp. 433-443
[27]	Hüffmeier, U., Bergboer, J.G., Becker, T. et al. J. Invest. Dermatol., 130 (2010),pp. 979-984
[28]	Helliwell, P.S., Taylor, W.J. Classification and diagnostic criteria for psoriatic arthritis Ann. Rheum. Dis., 64 (2005),pp. ii3-ii8
[29]	Hoss, E., Austin, H.R., Batie, S.F. et al. Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin Arch. Dermatol. Res., 305 (2013),pp. 867-878
[30]	Jackson, B., Tilli, C.M., Hardman, M.J. et al. Late cornified envelope family in differentiating epithelia–response to calcium and ultraviolet irradiation J. Invest. Dermatol., 124 (2005),pp. 1062-1070
[31]	Julia, A., Tortosa, R., Hernanz, J.M. et al. Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes Hum. Mol. Genet., 21 (2012),pp. 4549-4557
[32]	Li, M., Wu, Y., Chen, G. et al. J. Invest. Dermatol., 131 (2011),pp. 1639-1643
[33]	Liu, Y., Helms, C., Liao, W. et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci PLoS Genet., 4 (2008),p. e1000041
[34]	Lowes, M.A., Bowcock, A.M., Krueger, J.G. Pathogenesis and therapy of psoriasis Nature, 445 (2007),pp. 866-873
[35]	Lu, X., Guo, J., Zhou, X. et al. Ann. Rheum. Dis., 70 (2011),pp. 1648-1651
[36]	Marshall, D., Hardman, M., Nield, K. et al. Differentially expressed late constituents of the epidermal cornified envelope Proc. Natl. Acad. Sci. USA, 98 (2001),pp. 13031-13036
[37]	Oostveen, A.M., Bergboer, J.G., van de Kerkhof, P.C. et al. Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis Acta Derm. Venereol., 94 (2014),pp. 667-671
[38]	Parisi, R., Symmons, D.P., Griffiths, C.E. et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence J. Invest. Dermatol., 133 (2013),pp. 377-385
[39]	Riveira-Munoz, E., He, S.-M., Escaramís, G. et al. J. Invest. Dermatol., 131 (2010),pp. 1105-1109
[40]	Talamonti, M., Botti, E., Galluzzo, M. et al. Br. J. Dermatol., 169 (2013),pp. 458-463
[41]	Tang, H., Jin, X., Li, Y. et al. A large-scale screen for coding variants predisposing to psoriasis Nat. Genet., 46 (2014),pp. 45-50
[42]	Tyszkiewicz, T., Jarzab, M., Szymczyk, C. et al. Epidermal differentiation complex (locus 1q21) gene expression in head and neck cancer and normal mucosa Folia Histochem. Cytobiol., 52 (2014),pp. 79-89
[43]	Xu, L., Li, Y., Zhang, X. et al. Br. J. Dermatol., 165 (2011),pp. 882-887
[44]	Zenewicz, L.A., Abraham, C., Flavell, R.A. et al. Unraveling the genetics of autoimmunity Cell, 140 (2010),pp. 791-797
[45]	Zhang, X.J., Huang, W., Yang, S. et al. Nat. Genet., 41 (2009),pp. 205-210
[46]	Zheng, H.F., Zuo, X.B., Lu, W.S. et al. J. Dermatol. Sci., 61 (2011),pp. 124-128