A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1 and HBB Loci in Chinese Indigenous Dogs

Ruoxi Fan^{a, #},
Fei Liu^{b, #},
Hong Wu^a,
Shifang Wu^b,
Chunling Zhu^b,
Yan Li^b,
Guodong Wang^{b
, ,},
Yaping Zhang^{a, b
, ,}

a.
Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China
b.
State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

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Corresponding author: E-mail address: wanggd@mail.kiz.ac.cn (Guodong Wang); E-mail address: zhangyp@mail.kiz.ac.cn (Yaping Zhang)

These authors contributed equally to this work.

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These authors contributed equally to this work.

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[1]	Adzhubei, I.A., Schmidt, S., Peshkin, L. et al. A method and server for predicting damaging missense mutations Nat. Methods, 7 (2010),pp. 248-249
[2]	Akey, J.M., Zhang, G., Zhang, K. et al. Interrogating a high-density SNP map for signatures of natural selection Genome Res., 12 (2002),pp. 1805-1814
[3]	Beall, C.M., Cavalleri, G.L., Deng, L. et al. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders Proc. Natl. Acad. Sci. USA, 107 (2010),pp. 11459-11464
[4]	Bigham, A., Bauchet, M., Pinto, D. et al. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data PLoS Genet., 6 (2010),p. e1001116
[5]	Gou, X., Wang, Z., Li, N. et al. Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia Genome Res., 24 (2014),pp. 1308-1315
[6]	Ji, L.D., Qiu, Y.Q., Xu, J. et al. Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations Mol. Biol. Evol., 29 (2012),pp. 3359-3370
[7]	Key, J., Scheuermann, T.H., Anderson, P.C. et al. Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B J. Am. Chem. Soc., 131 (2009),pp. 17647-17654
[8]	Lee, F.S., Percy, M.J. The HIF pathway and erythrocytosis Annu. Rev. Pathol., 6 (2011),pp. 165-192
[9]	Mairbaurl, H., Weber, R.E. Oxygen transport by hemoglobin Compr. Physiol., 2 (2012),pp. 1463-1489
[10]	Natarajan, C., Inoguchi, N., Weber, R.E. et al. Epistasis among adaptive mutations in deer mouse hemoglobin Science, 340 (2013),pp. 1324-1327
[11]	Sabeti, P.C., Reich, D.E., Higgins, J.M. et al. Detecting recent positive selection in the human genome from haplotype structure Nature, 419 (2002),pp. 832-837
[12]	Savolainen, P., Zhang, Y.P., Luo, J. et al. Genetic evidence for an East Asian origin of domestic dogs Science, 298 (2002),pp. 1610-1613
[13]	Simonson, T.S., Yang, Y., Huff, C.D. et al. Genetic evidence for high-altitude adaptation in Tibet Science, 329 (2010),pp. 72-75
[14]	Storz, J.F., Moriyama, H. Mechanisms of hemoglobin adaptation to high altitude hypoxia High Alt. Med. Biol., 9 (2008),pp. 148-157
[15]	Tang, K., Thornton, K.R., Stoneking, M. A new approach for using genome scans to detect recent positive selection in the human genome PLoS Biol., 5 (2007),p. e171
[16]	Wang, G.D., Fan, R.X., Zhai, W. et al. Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau Genome Biol. Evol., 6 (2014),pp. 2122-2128
[17]	Wang, G.D., Zhai, W., Yang, H.C. et al. The genomics of selection in dogs and the parallel evolution between dogs and humans Nat. Commun., 4 (2013),p. 1860
[18]	Weir, B.S., Cockerham, C.C. Estimating F-statistics for the analysis of population structure Evolution, 38 (1984),pp. 1358-1370
[19]	Yi, X., Liang, Y., Huerta-Sanchez, E. et al. Sequencing of 50 human exomes reveals adaptation to high altitude Science, 329 (2010),pp. 75-78
[20]	Zhao, M., Kong, Q.P., Wang, H.W. et al. Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau Proc. Natl. Acad. Sci. USA, 106 (2009),pp. 21230-21235

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doi: 10.1016/j.jgg.2015.02.006

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A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1 and HBB Loci in Chinese Indigenous Dogs

Corresponding author: E-mail address: wanggd@mail.kiz.ac.cn (Guodong Wang); E-mail address: zhangyp@mail.kiz.ac.cn (Yaping Zhang)

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doi: 10.1016/j.jgg.2015.02.006

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A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1 and HBB Loci in Chinese Indigenous Dogs

Corresponding author: E-mail address: wanggd@mail.kiz.ac.cn (Guodong Wang); E-mail address: zhangyp@mail.kiz.ac.cn (Yaping Zhang)

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