Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish

Yue Yuan^{a, b},
Jian Zhang^{b
, ,},
Qin Zhou^{a
, ,}

a.
The Division of Molecular Nephrology and the Creative Training Center for Undergraduates, the M.O.E. Key Laboratory of Laboratory Medical Diagnostics, the College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China
b.
State Key Laboratory of Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

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Corresponding author: E-mail address: jianzhang84@genetics.ac.cn (Jian Zhang); E-mail address: zhouqin@cqmu.edu.cn (Qin Zhou)

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[4]	Hong, S., Laimins, L.A. The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation PLoS Pathog., 9 (2013),p. e1003295
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[8]	Kan, Z., Zheng, H., Liu, X. et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma Genome Res., 23 (2013),pp. 1422-1433
[9]	Liberzon, A., Subramanian, A., Pinchback, R. et al. Molecular signatures database (MSigDB) 3.0 Bioinformatics, 27 (2011),pp. 1739-1740
[10]	Nguyen, A.T., Emelyanov, A., Koh, C.H. et al. Dis. Model. Mech., 4 (2011),pp. 801-813
[11]	Parkin, D.M. The global health burden of infection-associated cancers in the year 2002 Int. J. Cancer, 118 (2006),pp. 3030-3044
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[13]	Wei, Y., Van Nhieu, J.T., Prigent, S. et al. Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, β-catenin expression, and clinical features Hepatology, 36 (2002),pp. 692-701
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doi: 10.1016/j.jgg.2015.11.003

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Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish

Corresponding author: E-mail address: jianzhang84@genetics.ac.cn (Jian Zhang); E-mail address: zhouqin@cqmu.edu.cn (Qin Zhou)

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doi: 10.1016/j.jgg.2015.11.003

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Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish

Corresponding author: E-mail address: jianzhang84@genetics.ac.cn (Jian Zhang); E-mail address: zhouqin@cqmu.edu.cn (Qin Zhou)

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