Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice

1.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China
2.
School of Agronomy, Anhui Agricultural University, Hefei 230036, China
3.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China
4.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China
5.
School of Agronomy, Anhui Agricultural University, Hefei 230036, China
6.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China
7.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China
8.
School of Agronomy, Anhui Agricultural University, Hefei 230036, China

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[6]	Xing, H.-L., Dong, L., Wang, Z.-P. et al. A CRISPR/Cas9 toolkit for multiplex genome editing in plants BMC Plant Biol., 14 (2014),p. 327
[7]	Xu, R.-F., Li, H., Qin, R.-Y. et al. Generation of inheritable and “transgene clean” targeted genome-modified rice in later generations using the CRISPR/Cas9 system Sci. Rep., 5 (2015)
[8]	Zhang, H., Zhang, J., Wei, P. et al. The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation Plant Biotechnol. J., 12 (2014),pp. 797-807
[9]	Zhang, Z., Mao, Y., Ha, S. et al. Plant Cell Rep., 7 (2015),pp. 1519-1533
[10]	Zuo, J., Li, J. Molecular genetic dissection of quantitative trait loci regulating rice grain size Annu. Rev. Genet., 48 (2014),pp. 99-118

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