A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs

Qitao Jia^{1, 2, 3, #},
Chunwei Cao^{1, 2, 3, #},
Hai Tang^{1, 2, 3},
Ying Zhang^{1, 2, 3},
Qiantao Zheng^{1, 2, 3},
Xiao Wang^{1, 2, 3},
Rui Zhang^{1, 2, 3},
Xianlong Wang^{1, 2, 3},
Ailing Luo^{1, 2, 3},
Hong Wei^{4, 5},
Anming Meng^{6, 7},
Qi Zhou^{8, 9, 10},
Hongmei Wang^{8, 9, 10
, ,},
Jianguo Zhao^{8, 9, 10
, ,}

1.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2.
University of Chinese Academy of Sciences, Beijing 100049, China
3.
Chinese Swine Mutagenesis Consortium, China
4.
Department of Laboratory, College of Basic Medicine, Third Military Medical University, Chongqing 400038, China
5.
Chinese Swine Mutagenesis Consortium, China
6.
School of Life Sciences, Tsinghua University, Beijing 100084, China
7.
Chinese Swine Mutagenesis Consortium, China
8.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
9.
University of Chinese Academy of Sciences, Beijing 100049, China
10.
Chinese Swine Mutagenesis Consortium, China

More Information

Corresponding author: E-mail address: Wanghm@ioz.ac.cn (Hongmei Wang); E-mail address: zhaojg@ioz.ac.cn (Jianguo Zhao)

These authors contributed equally to this work.

摘要

These authors contributed equally to this work.

注释:

HTML全文

参考文献(20)

[1]	Andersson, L. Melanocortin receptor variants with phenotypic effects in horse, pig, and chicken Ann. N. Y. Acad. Sci., 994 (2003),pp. 313-318
[2]	Andersson, L. Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin. Cold Spring Harb Symp. Quant. Biol., 74 (2009),pp. 319-325
[3]	Barsh, G.S. The genetics of pigmentation: from fancy genes to complex traits Trends Genet., 12 (1996),pp. 299-305
[4]	Eggermont, A.M., Spatz, A., Robert, C. Cutaneous melanoma Lancet, 383 (2014),pp. 816-827
[5]	Giuffra, E., Tornsten, A., Marklund, S. et al. A large duplication associated with dominant white color in pigs originated by homologous recombination between LINE elements flanking KIT Mamm. Genome, 13 (2002),pp. 569-577
[6]	Hai, T., Teng, F., Guo, R. et al. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system Cell Res., 24 (2014),pp. 372-375
[7]	Kijas, J.M., Wales, R., Tornsten, A. et al. Melanocortin receptor 1 (MC1R) mutations and coat color in pigs Genetics, 150 (1998),pp. 1177-1185
[8]	Klungland, H., Vage, D.I., Gomez-Raya, L. et al. The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination Mamm. Genome, 6 (1995),pp. 636-639
[9]	Marklund, S., Kijas, J., Rodriguez-Martinez, H. et al. Molecular basis for the dominant white phenotype in the domestic pig Genome Res., 8 (1998),pp. 826-833
[10]	Miyagi, R., Terai, Y. The diversity of male nuptial coloration leads to species diversity in Lake Victoria cichlids Genes Genet. Syst., 88 (2013),pp. 145-153
[11]	Newton, J.M., Wilkie, A.L., He, L. et al. Melanocortin 1 receptor variation in the domestic dog Mamm. Genome, 11 (2000),pp. 24-30
[12]	Robbins, L.S., Nadeau, J.H., Johnson, K.R. et al. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function Cell, 72 (1993),pp. 827-834
[13]	Schook, L.B., Collares, T.V., Darfour-Oduro, K.A. et al. Unraveling the swine genome: implications for human health Annu. Rev. Anim. Biosci., 3 (2015),pp. 219-244
[14]	Slominski, A., Tobin, D.J., Shibahara, S. et al. Melanin pigmentation in mammalian skin and its hormonal regulation Physiol. Rev., 84 (2004),pp. 1155-1228
[15]	Sun, Z., Wang, G., Yang, X. et al. Experimental study on effect of natural hirudin on vein congestion of random skin flap in porcine models Chin. J. Reparative Reconstr. Surg., 22 (2008),pp. 1296-1300
[16]	Takeuchi, S., Suzuki, H., Yabuuchi, M. et al. A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the chicken Biochim. Biophys. Acta, 1308 (1996),pp. 164-168
[17]	Wang, X., Cao, C., Huang, J. et al. One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system Sci. Rep., 6 (2016),p. 20620
[18]	Zhang, B., Chen, B., Ma, D. et al. Establishment of a Bama miniature swine model of chronic myocardial ischemic models by thoracoscopy J. Med. Res., 43 (2014),pp. 104-107
[19]	Zhang, Y., Liu, X., Xie, L. et al. Variation of nitric oxide synthase in penis of Bama mini-pigs with diabetic erectile dysfunction Prog. Veterinary Med., 31 (2010),pp. 28-31
[20]	Zhou, X., Wang, L., Du, Y. et al. Efficient generation of gene-modified pigs harboring precise orthologous human mutation via CRISPR/Cas9-induced homology-directed repair in zygotes Hum. Mutat., 37 (2016),pp. 110-118

施引文献

资源附件(0)

访问统计

点击查看大图

计量

文章访问数: 85
HTML全文浏览量: 31
PDF下载量: 8
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

doi: 10.1016/j.jgg.2017.02.003

计量

A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs

Corresponding author: E-mail address: Wanghm@ioz.ac.cn (Hongmei Wang); E-mail address: zhaojg@ioz.ac.cn (Jianguo Zhao)

计量

目录

留言板

doi: 10.1016/j.jgg.2017.02.003

计量

出版历程

A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs

Corresponding author: E-mail address: Wanghm@ioz.ac.cn (Hongmei Wang); E-mail address: zhaojg@ioz.ac.cn (Jianguo Zhao)

计量

出版历程

目录