Mediator complex components are frequent targets for genetic alterations in various types of human cancer

Libin Deng^{1, 2
, ,},
Cheng Zhang³,
Duling Miao⁴,
Xiaoli Tang⁵,
Shiwen Luo^{6, 7},
Hong-Bo Xin⁸,
Huidong Shi^{9, 10
, ,}

1.
Institute of Translational Medicine, Nanchang University, Nanchang 330031, China
2.
Medical School of Nanchang University, Nanchang 330031, China
3.
Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
4.
Institute of Translational Medicine, Nanchang University, Nanchang 330031, China
5.
Medical School of Nanchang University, Nanchang 330031, China
6.
Medical School of Nanchang University, Nanchang 330031, China
7.
Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
8.
Institute of Translational Medicine, Nanchang University, Nanchang 330031, China
9.
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
10.
Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA

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Corresponding author: E-mail address: denglb1937@163.com (Libin Deng); E-mail address: hshi@augusta.edu (Huidong Shi)

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[4]	Chapuy, B., McKeown, M.R., Lin, C.Y. et al. Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma Cancer Cell, 24 (2013),pp. 777-790
[5]	Chipumuro, E., Marco, E., Christensen, C.L. et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer Cell, 159 (2014),pp. 1126-1139
[6]	Christensen, C.L., Kwiatkowski, N., Abraham, B.J. et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor Cancer Cell, 26 (2014),pp. 909-922
[7]	Clarke, P.A., Ortiz-Ruiz, M.-J., TePoele, R. et al. Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases eLife, 5 (2016)
[8]	Dehainault, C., Garancher, A., Castera, L. et al. Hum. Mol. Genet., 23 (2014),pp. 5243-5250
[9]	Jiang, Y.Y., Lin, D.C., Mayakonda, A. et al. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma Gut, 66 (2017),pp. 1358-1368
[10]	Kampjarvi, K., Kim, N.H., Keskitalo, S. et al. Prostate, 76 (2016),pp. 22-31
[11]	Kampjarvi, K., Park, M.J., Mehine, M. et al. Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas Hum. Mutat., 35 (2014),pp. 1136-1141
[12]	Kandaswamy, R., Sava, G.P., Speedy, H.E. et al. Genetic predisposition to chronic lymphocytic leukemia is mediated by a BMF super-enhancer polymorphism Cell Rep., 16 (2016),pp. 2061-2067
[13]	Lim, W.K., Ong, C.K., Tan, J. et al. Nat. Genet., 46 (2014),pp. 877-880
[14]	Mansour, M.R., Abraham, B.J., Anders, L. et al. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element Science, 346 (2014),pp. 1373-1377
[15]	Pelish, H.E., Liau, B.B., II, Nitulescu, Tangpeerachaikul, A. et al. Mediator kinase inhibition further activates super-enhancer-associated genes in AML Nature, 526 (2015),pp. 273-276
[16]	Pott, S., Lieb, J.D. What are super-enhancers? Nat. Genet., 47 (2015),pp. 8-12
[17]	Spaeth, J.M., Kim, N.H., Boyer, T.G. Mediator and human disease Semin. Cell Dev. Biol., 22 (2011),pp. 776-787
[18]	Turunen, M., Spaeth, J.M., Keskitalo, S. et al. Cell Rep., 7 (2014),pp. 654-660
[19]	Yin, J.-W., Wang, G. The Mediator complex: a master coordinator of transcription and cell lineage development Development, 141 (2014),pp. 977-987
[20]	Zhang, Z., Peng, H., Wang, X. et al. Preclinical efficacy and molecular mechanism of targeting CDK7-dependent transcriptional addiction in ovarian cancer Mol. Cancer Ther., 16 (2017),pp. 1739-1750

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doi: 10.1016/j.jgg.2017.08.006

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Mediator complex components are frequent targets for genetic alterations in various types of human cancer

Corresponding author: E-mail address: denglb1937@163.com (Libin Deng); E-mail address: hshi@augusta.edu (Huidong Shi)

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doi: 10.1016/j.jgg.2017.08.006

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Mediator complex components are frequent targets for genetic alterations in various types of human cancer

Corresponding author: E-mail address: denglb1937@163.com (Libin Deng); E-mail address: hshi@augusta.edu (Huidong Shi)

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