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Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains

Xueyun Huo Xiulin Zhang Yihan Liu Yizhu Sun Yu Ren Changlong Li Xiaoyan Du Zhenwen Chen

Xueyun Huo, Xiulin Zhang, Yihan Liu, Yizhu Sun, Yu Ren, Changlong Li, Xiaoyan Du, Zhenwen Chen. Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains[J]. Journal of Genetics and Genomics, 2018, 45(10): 553-556. doi: 10.1016/j.jgg.2018.07.010
Citation: Xueyun Huo, Xiulin Zhang, Yihan Liu, Yizhu Sun, Yu Ren, Changlong Li, Xiaoyan Du, Zhenwen Chen. Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains[J]. Journal of Genetics and Genomics, 2018, 45(10): 553-556. doi: 10.1016/j.jgg.2018.07.010

doi: 10.1016/j.jgg.2018.07.010

Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains

More Information
  • [1] Fu, Y., Foden, J.A., Khayter, C. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells Nat. Biotechnol., 31 (2013),pp. 822-826
    [2] Gerlai, R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci., 19 (1996),pp. 177-181
    [3] Ho, B.X., Loh, S.J.H., Chan, W.K. et al. Int. J. Mol. Sci., 19 (2018)
    [4] Hsu, P.D., Scott, D.A., Weinstein, J.A. et al. DNA targeting specificity of RNA-guided Cas9 nucleases Nat. Biotechnol., 31 (2013),pp. 827-832
    [5] Huo, X., Du, Y., Lu, J. et al. Analysis of microsatellite instability in CRISPR/Cas9 editing mice Mutat. Res., 797–799 (2017),pp. 1-6
    [6] Moorehead, R.A., Sanchez, O.H., Baldwin, R.M. et al. Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma Oncogene, 22 (2003),pp. 853-857
    [7] Schaefer, K.A., Wu, W.H., Colgan, D.F. et al. Nat. Methods, 14 (2017),pp. 547-548
    [8] Teng, X., Dayhoff-Brannigan, M., Cheng, W.C. et al. Genome-wide consequences of deleting any single gene Mol. Cell, 52 (2013),pp. 485-494
    [9] Zhang, F., Wen, Y., Guo, X. CRISPR/Cas9 for genome editing: progress, implications and challenges Hum. Mol. Genet., 23 (2014),pp. 40-46
    [10] Zuo, B., Du, X., Zhao, J. et al. Analysis of microsatellite polymorphism in inbred knockout mice PLoS One, 7 (2012),p. e34555
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出版历程
  • 收稿日期:  2018-01-16
  • 录用日期:  2018-07-04
  • 修回日期:  2018-05-24
  • 网络出版日期:  2018-10-10
  • 刊出日期:  2018-10-20

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