WDR74 functions as a novel coactivator in TGF-β signaling

Jinquan Liu^{a, b},
Meiling Zhao^a,
Bo Yuan^a,
Shuchen Gu^a,
Mingjie Zheng^{a, c},
Jian Zou^c,
Jianping Jin^b,
Ting Liu^{a, d
, ,},
Xin-Hua Feng^{a, e
, ,}

a.
MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China
b.
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
c.
Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310058, China
d.
Department of Cell Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China
e.
Department of Molecular & Cellular Biology and Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA

More Information

Corresponding author: E-mail address: liuting518@zju.edu.cn (Ting Liu); E-mail address: fenglab@zju.edu.cn (Xin-Hua Feng)

摘要

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Abstract: Smads are critical intracellular signal transducers for transforming growth factor-β (TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-β signaling.
- WDR74 /
- TGF-β signaling /
- Transcription /
- Growth inhibition /
- EMT

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参考文献(46)

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