The forty years of medical genetics in China

Lei Cai^{a, b
, ,},
Lan Alice Zheng^c,
Lin He^{a, b
, ,}

a.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Collaborative Innovation Center for Genetics and Development, Shanghai Jiao Tong University, Shanghai 200240, China
b.
Shanghai Center for Women and Children's Health, Shanghai 200062, China
c.
Stanley Center, Broad Institute, Cambridge, MA 02142, USA

More Information

Corresponding author: E-mail address: lcai@sjtu.edu.cn (Lei Cai); E-mail address: helin@sjtu.edu.cn (Lin He)

摘要

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Abstract: Medical genetics is the newest cutting-edge discipline that focuses on solving medical problems using genetics knowledge and methods. In China, medical genetics research activities initiated from a poor inner basis but a prosperous outer environment. During the 40 years of reform and opening-up policy, Chinese scientists contributed significantly in the field of medical genetics, garnering considerable attention worldwide. In this review, we highlight the significant findings and/or results discovered by Chinese scientists in monogenic diseases, complex diseases, cancer, genetic diagnosis, as well as gene manipulation and gene therapy. Due to these achievements, China is widely recognized to be at the forefront of medical genetics research and development. However, the significant progress and development that has been achieved could not have been accomplished without sufficient funding and a well-constructed logistics network. The successful implementation of translational and precise medicine sourced from medical genetics will depend on an open ethics policy and intellectual property protection, along with strong support at the national industry level.
- Medical genetics /
- GWAS /
- CRISPR /
- Cancer /
- Monogenic diseases /
- Complex diseases /
- Genetic diagnosis /
- Gene therapy

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