The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis

Yilai Shu^{1, 17, 2, #},
Lijun Wang^{3, #},
Xiaoting Cheng^{4, 22, 5},
Chayada Tangshewinsirikul^{6, 7},
Weili Shi^{8, 9},
Yasheng Yuan^{10, 24, 11},
Zhiqiang Yan¹²,
Huawei Li^{13, 23, 14},
Jun Shen^{15, 16
, ,},
Bing Chen^{20, 21, 18
, ,},
Weiguo Zou^{19
, ,}

1.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
2.
NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
3.
State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
4.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
5.
NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
6.
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA
7.
Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
8.
Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
9.
Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, 450003, China
10.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
11.
NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
12.
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Human Phenome Institute, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Institute of Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China
13.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
14.
NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
15.
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA
16.
Harvard Medical School Center for Hereditary Deafness, Boston, MA, 02115, USA
17.
Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
18.
NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
19.
State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
20.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
21.
Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
22.
Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
23.
Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
24.
Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China

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Corresponding author: E-mail address: jshen5@bwh.harvard.edu (Jun Shen); E-mail address: bingchen@fudan.edu.cn (Bing Chen); E-mail address: zouwg94@sibcb.ac.cn (Weiguo Zou)

These authors contributed equally to this work.

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These authors contributed equally to this work.

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参考文献(20)

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doi: 10.1016/j.jgg.2019.09.003

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The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis

Corresponding author: E-mail address: jshen5@bwh.harvard.edu (Jun Shen); E-mail address: bingchen@fudan.edu.cn (Bing Chen); E-mail address: zouwg94@sibcb.ac.cn (Weiguo Zou)

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doi: 10.1016/j.jgg.2019.09.003

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The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis

Corresponding author: E-mail address: jshen5@bwh.harvard.edu (Jun Shen); E-mail address: bingchen@fudan.edu.cn (Bing Chen); E-mail address: zouwg94@sibcb.ac.cn (Weiguo Zou)

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