Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus

Tianyi Qiu^{1, 1},
Tiantian Mao^{2, 1},
Yuan Wang²,
Mengdi Zhou²,
Jingxuan Qiu²,
Jianwei Wang³,
Jianqing Xu^{4
, ,},
Zhiwei Cao^{5
, ,}

1.
Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200433, China
2.
Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China
3.
NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, China
4.
Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200433, China
5.
Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China

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Corresponding author: E-mail address: xujianqing@shphc.org.cn (Jianqing Xu); E-mail address: zwcao@tongji.edu.cn (Zhiwei Cao)

These authors contributed equally to this work.

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These authors contributed equally to this work.

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Fig. 1. Antigenic clustering and potential CREs between 2019-nCoV and SARS. A: Antigenic clustering of S proteins for 53 representative CoVs based on the 6th epitope regions. One cluster is marked in cyan, and the other is marked in pink. The 2019-nCoV is marked as WH Human1-2019-nCoV here. B: Details in the 2019-nCoV cluster with score matrix of antigenic similarity. C: Position mapping of potential CREs on the modeled structure of 2019-nCoV (WH-Human1-2019-nCoV).D: Position mapping of potential CREs on the modeled structure of SARS-CoV B039 (Q4JDN3). E: Sequence alignment of S proteins for 2019-nCoV and SARS-CoVs. Epitope regions are highlighted in red, and five essential human ACE2-binding sites are highlighted in blue. Sites are numbered based on the S protein sequence of 2019-nCoV. Dot in the sequence of SARS-CoV represents gap insertion. F: Surface view of CREs and ACE2-binding sites. CREs are marked in red, and ACE2-binding sites are marked in cyan. CRE, cross-reactive epitope; CoV, coronavirus; SARS, severe acute respiratory syndrome.

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doi: 10.1016/j.jgg.2020.01.003

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Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus

Corresponding author: E-mail address: xujianqing@shphc.org.cn (Jianqing Xu); E-mail address: zwcao@tongji.edu.cn (Zhiwei Cao)

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doi: 10.1016/j.jgg.2020.01.003

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Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus

Corresponding author: E-mail address: xujianqing@shphc.org.cn (Jianqing Xu); E-mail address: zwcao@tongji.edu.cn (Zhiwei Cao)

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