Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells

1.
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada
2.
Department of Human Genetics, McGill University, Montréal, Quebec, H3A 0C7, Canada
3.
Department of Human Genetics, University of Chicago, IL, 60637, USA
4.
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada
5.
McGill University and Genome Québec Innovation Centre, Montréal, Quebec, H3A 0G1, Canada
6.
McGill University and Genome Québec Innovation Centre, Montréal, Quebec, H3A 0G1, Canada
7.
Department of Human Genetics, McGill University, Montréal, Quebec, H3A 0C7, Canada
8.
McGill University and Genome Québec Innovation Centre, Montréal, Quebec, H3A 0G1, Canada
9.
Department of Human Genetics, McGill University, Montréal, Quebec, H3A 0C7, Canada
10.
Center for Pediatric Genomic Medicine, Kansas City, MO, 64108, USA
11.
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada
12.
Centre intersectoriel en santé durable, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada

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Corresponding author: E-mail address: catherine.laprise@uqac.ca (Catherine Laprise)

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Fig. 1. Methylation and expression profiles of GSDMA in samples from naïve CD4⁺ T cells. A: The 17q12-21 region from the fourth to the seventh haplotype blocks, the genes located in this region, and the strand of these are shown. Genes in grey are those not expressed by naïve CD4⁺ T cells. All SNPs in eQTLs and mQTLs that were identified in naïve CD4⁺ T cells for GSDMA are shown in the fourth and fifth haplotype blocks. B: The two CpGs involved in mQTLs, where r is depicted for correlations between adjacent methylation sites. C: Correlation between the two methylation sites included in mQTLs and the one between each of them and GSDMA expression. D: Significant differences between counts for individuals with homozygous genotype for the alternative alleles of all the 20 associated SNPs compared to other individuals, as well as for the individuals with heterozygous genotypes for all the 20 associated SNPs compared to other individuals. Alt = homozygous for the alternative allele; het = heterozygous genotype.

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参考文献(10)

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doi: 10.1016/j.jgg.2020.03.002

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Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells

Corresponding author: E-mail address: catherine.laprise@uqac.ca (Catherine Laprise)

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doi: 10.1016/j.jgg.2020.03.002

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Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells

Corresponding author: E-mail address: catherine.laprise@uqac.ca (Catherine Laprise)

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