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Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity

Jinming Mu,  Sin Man Lam,  Guanghou Shui

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文章导航 > Journal of Genetics and Genomics  > 2023 > 优先出版
Jinming Mu, Sin Man Lam, Guanghou Shui. Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity[J]. 遗传学报. doi: 10.1016/j.jgg.2023.06.006
引用本文: Jinming Mu, Sin Man Lam, Guanghou Shui. Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity[J]. 遗传学报. doi: 10.1016/j.jgg.2023.06.006
shu
Jinming Mu, Sin Man Lam, Guanghou Shui. Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2023.06.006
Citation: Jinming Mu, Sin Man Lam, Guanghou Shui. Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2023.06.006
shu

Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity

doi: 10.1016/j.jgg.2023.06.006

  • 1 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;

  • 2 University of Chinese Academy of Sciences, Beijing 100101, China;

  • 3 Lipidall Technologies Company Limited, Changzhou, Jiangsu 213000, China

基金项目: 

This work was financially supported by grants from National Key R&D Program of China (2018YFA0506900, 2018YFA0800901), National Natural Science Foundation of China NSFC92057202, and the Chinese Academy of Sciences (XDB39050900).

详细信息
    通讯作者:

    Sin Man Lam,Email:smlam@genetics.ac.cn

    Guanghou Shui,Email:ghshui@genetics.ac.cn

Emerging roles and therapeutic potentials of sphingolipids in pathophysiology —— emphasis on fatty acyl heterogeneity

  • 1 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;

  • 2 University of Chinese Academy of Sciences, Beijing 100101, China;

  • 3 Lipidall Technologies Company Limited, Changzhou, Jiangsu 213000, China

Funds: 

This work was financially supported by grants from National Key R&D Program of China (2018YFA0506900, 2018YFA0800901), National Natural Science Foundation of China NSFC92057202, and the Chinese Academy of Sciences (XDB39050900).

    摘要
  • 摘要: Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling molecules in various physiological and pathological processes. A myriad of studies have shown that abnormal levels of sphingolipids and their metabolic enzymes are associated with a variety of human diseases. Moreover, blood sphingolipids can also be used as biomarkers for disease diagnosis. This review summarizes the biosynthesis, metabolism, and pathological roles of sphingolipids, with emphasis on the biosynthesis of ceramide, the precursor for the biosynthesis of complex sphingolipids with different fatty acyl chains. The possibility of using sphingolipids for disease prediction, diagnosis, and treatment is also discussed. Targeting endogenous ceramides and complex sphingolipids along with their specific fatty acyl chain to promote future drug development will also be discussed.
    Abstract: Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling molecules in various physiological and pathological processes. A myriad of studies have shown that abnormal levels of sphingolipids and their metabolic enzymes are associated with a variety of human diseases. Moreover, blood sphingolipids can also be used as biomarkers for disease diagnosis. This review summarizes the biosynthesis, metabolism, and pathological roles of sphingolipids, with emphasis on the biosynthesis of ceramide, the precursor for the biosynthesis of complex sphingolipids with different fatty acyl chains. The possibility of using sphingolipids for disease prediction, diagnosis, and treatment is also discussed. Targeting endogenous ceramides and complex sphingolipids along with their specific fatty acyl chain to promote future drug development will also be discussed.
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    • 参考文献(141)
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  • 收稿日期:  2023-04-01
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