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Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment

Yuxi Chen,  Xiao Luo,  Rui Kang,  Kaixin Cui,  Jianping Ou,  Xiya Zhang,  Puping Liang

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文章导航 > Journal of Genetics and Genomics  > 2023 > 优先出版
Yuxi Chen, Xiao Luo, Rui Kang, Kaixin Cui, Jianping Ou, Xiya Zhang, Puping Liang. Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment[J]. 遗传学报. doi: 10.1016/j.jgg.2023.07.007
引用本文: Yuxi Chen, Xiao Luo, Rui Kang, Kaixin Cui, Jianping Ou, Xiya Zhang, Puping Liang. Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment[J]. 遗传学报. doi: 10.1016/j.jgg.2023.07.007
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Yuxi Chen, Xiao Luo, Rui Kang, Kaixin Cui, Jianping Ou, Xiya Zhang, Puping Liang. Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2023.07.007
Citation: Yuxi Chen, Xiao Luo, Rui Kang, Kaixin Cui, Jianping Ou, Xiya Zhang, Puping Liang. Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2023.07.007
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Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment

doi: 10.1016/j.jgg.2023.07.007

  • a MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

  • b Center for Reproductive Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou 510630, China. oof

基金项目: 

This work was supported by the National Natural Science Foundation (32001063, 82201769), the Guangdong Special Support Program (2019BT02Y276), the Guangdong Basic and Applied Basic Research Foundation (2021A1515010759, 2023A1515010176), the grant from MOE Key Laboratory of Gene Function and Regulation, the Guangzhou Science and Technology Planning Project (202201020411, 2023A04J1952), and the Fundamental Research Funds for the Central Universities, Sun Yat-sen University (23ptpy59).

详细信息
    通讯作者:

    Xiya Zhang,Email addresses:zhangxiya@mail.sysu.edu.cn

    Puping Liang,Email addresses:liangpp5@mail.sysu.edu.cn

Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment

  • a MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

  • b Center for Reproductive Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou 510630, China. oof

Funds: 

This work was supported by the National Natural Science Foundation (32001063, 82201769), the Guangdong Special Support Program (2019BT02Y276), the Guangdong Basic and Applied Basic Research Foundation (2021A1515010759, 2023A1515010176), the grant from MOE Key Laboratory of Gene Function and Regulation, the Guangzhou Science and Technology Planning Project (202201020411, 2023A04J1952), and the Fundamental Research Funds for the Central Universities, Sun Yat-sen University (23ptpy59).

    摘要
  • 摘要:

    Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide, causing pain, disability, and decreased quality of life. The balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of OA. Currently, there is a lack of effective therapeutic strategies for OA treatment. With the development of CRISPR-based genome, epigenome, and RNA editing tools, OA treatment has been improved by targeting genetic risk factors, activating chondrogenic elements, and modulating inflammatory regulators. Supported by cell therapy and in vivo delivery vectors, genome, epigenome, and RNA editing tools may provide a promising approach for personalized OA therapy. This review summarizes CRISPR-based genome, epigenome, and RNA editing tools that can be applied to the treatment of OA and provides new insights into the development of CRISPR-based therapeutics for OA treatment. Moreover, in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.

    Abstract:

    Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide, causing pain, disability, and decreased quality of life. The balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of OA. Currently, there is a lack of effective therapeutic strategies for OA treatment. With the development of CRISPR-based genome, epigenome, and RNA editing tools, OA treatment has been improved by targeting genetic risk factors, activating chondrogenic elements, and modulating inflammatory regulators. Supported by cell therapy and in vivo delivery vectors, genome, epigenome, and RNA editing tools may provide a promising approach for personalized OA therapy. This review summarizes CRISPR-based genome, epigenome, and RNA editing tools that can be applied to the treatment of OA and provides new insights into the development of CRISPR-based therapeutics for OA treatment. Moreover, in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.

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