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Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

Yuntao Sun,  Mengge Wang,  Qiuxia Sun,  Yan Liu,  Shuhan Duan,  Zhiyong Wang,  Yunyu Zhou,  Jun Zhong,  Yuguo Huang,  Xinyu Huang,  Qingxin Yang,  Xiangping Li,  Haoran Su,  Yan Cai,  Xiucheng Jiang,  Jing Chen,  Jiangwei Yan,  Shengjie Nie,  Liping Hu,  Junbao Yang,  Renkuan Tang,  Chuan-Chao Wang,  Chao Liu,  Xiaohui Deng,  Libing Yun,  Guanglin He

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文章导航 > Journal of Genetics and Genomics  > 2024 >  51(5): 517-530
Yuntao Sun, Mengge Wang, Qiuxia Sun, Yan Liu, Shuhan Duan, Zhiyong Wang, Yunyu Zhou, Jun Zhong, Yuguo Huang, Xinyu Huang, Qingxin Yang, Xiangping Li, Haoran Su, Yan Cai, Xiucheng Jiang, Jing Chen, Jiangwei Yan, Shengjie Nie, Liping Hu, Junbao Yang, Renkuan Tang, Chuan-Chao Wang, Chao Liu, Xiaohui Deng, Libing Yun, Guanglin He. Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people[J]. 遗传学报, 2024, 51(5): 517-530. doi: 10.1016/j.jgg.2023.10.002
引用本文: Yuntao Sun, Mengge Wang, Qiuxia Sun, Yan Liu, Shuhan Duan, Zhiyong Wang, Yunyu Zhou, Jun Zhong, Yuguo Huang, Xinyu Huang, Qingxin Yang, Xiangping Li, Haoran Su, Yan Cai, Xiucheng Jiang, Jing Chen, Jiangwei Yan, Shengjie Nie, Liping Hu, Junbao Yang, Renkuan Tang, Chuan-Chao Wang, Chao Liu, Xiaohui Deng, Libing Yun, Guanglin He. Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people[J]. 遗传学报, 2024, 51(5): 517-530. doi: 10.1016/j.jgg.2023.10.002
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Yuntao Sun, Mengge Wang, Qiuxia Sun, Yan Liu, Shuhan Duan, Zhiyong Wang, Yunyu Zhou, Jun Zhong, Yuguo Huang, Xinyu Huang, Qingxin Yang, Xiangping Li, Haoran Su, Yan Cai, Xiucheng Jiang, Jing Chen, Jiangwei Yan, Shengjie Nie, Liping Hu, Junbao Yang, Renkuan Tang, Chuan-Chao Wang, Chao Liu, Xiaohui Deng, Libing Yun, Guanglin He. Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people[J]. Journal of Genetics and Genomics, 2024, 51(5): 517-530. doi: 10.1016/j.jgg.2023.10.002
Citation: Yuntao Sun, Mengge Wang, Qiuxia Sun, Yan Liu, Shuhan Duan, Zhiyong Wang, Yunyu Zhou, Jun Zhong, Yuguo Huang, Xinyu Huang, Qingxin Yang, Xiangping Li, Haoran Su, Yan Cai, Xiucheng Jiang, Jing Chen, Jiangwei Yan, Shengjie Nie, Liping Hu, Junbao Yang, Renkuan Tang, Chuan-Chao Wang, Chao Liu, Xiaohui Deng, Libing Yun, Guanglin He. Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people[J]. Journal of Genetics and Genomics, 2024, 51(5): 517-530. doi: 10.1016/j.jgg.2023.10.002
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Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

doi: 10.1016/j.jgg.2023.10.002

  • a. West China School of Basic Science & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China;

  • b. Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan 610000, China;

  • c. Center for Archaeological Science, Sichuan University, Chengdu, Sichuan 610000, China;

  • d. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510275, China;

  • e. Guangzhou Forensic Science Institute, Guangzhou, Guangdong 510055, China;

  • f. Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing 400331, China;

  • g. School of Clinical Medical Sciences, North Sichuan Medical College, Nanchong, Sichuan 637100, China;

  • h. School of Basic Medical Sciences, North Sichuan Medical College, Nanchong, Sichuan 637100, China;

  • i. School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China;

  • j. School of Stomatology, North Sichuan Medical College, Nanchong, Sichuan 637100, China;

  • k. Department of Medical Laboratory, North Sichuan Medical College, Nanchong, Sichuan 637007, China;

  • l. School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China;

  • m. Anti-Drug Technology Center of Guangdong Province, Guangzhou, Guangdong 510230, China;

  • n. School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030600, China

基金项目: 

This work was supported by grants from the National Natural Science Foundation of China (82202078) and the Center for Archaeological Science of Sichuan University (23SASA01). We thank Prof. Etienne Patin and Prof. Lluis Quintana-Murci from the Human Evolutionary Genetics Unit of the Institute Pasteur for sharing the high-coverage genomes of 317 individuals from the Pacific region. We thank Prof. Mark Stoneking, Prof. Dang Liu at Max Planck Institute for Evolutionary Anthropology, and Prof. Wibhu Kutanan at Khon Kaen University for sharing genome-wide SNP data from Vietnam, Thailand, and Laos.

详细信息
    通讯作者:

    Mengge Wang,E-mail:Menggewang2021@163.com

    Xiaohui Deng,E-mail:dengxhhappy@126.com

    Libing Yun,E-mail:yunlibing@scu.edu.cn

    Guanglin He,E-mail:guanglinhescu@163.com

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

  • a. West China School of Basic Science & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China;

  • b. Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan 610000, China;

  • c. Center for Archaeological Science, Sichuan University, Chengdu, Sichuan 610000, China;

  • d. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510275, China;

  • e. Guangzhou Forensic Science Institute, Guangzhou, Guangdong 510055, China;

  • f. Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing 400331, China;

  • g. School of Clinical Medical Sciences, North Sichuan Medical College, Nanchong, Sichuan 637100, China;

  • h. School of Basic Medical Sciences, North Sichuan Medical College, Nanchong, Sichuan 637100, China;

  • i. School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China;

  • j. School of Stomatology, North Sichuan Medical College, Nanchong, Sichuan 637100, China;

  • k. Department of Medical Laboratory, North Sichuan Medical College, Nanchong, Sichuan 637007, China;

  • l. School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China;

  • m. Anti-Drug Technology Center of Guangdong Province, Guangzhou, Guangdong 510230, China;

  • n. School of Forensic Medicine, Shanxi Medical University, Jinzhong, Shanxi, 030600, China

Funds: 

This work was supported by grants from the National Natural Science Foundation of China (82202078) and the Center for Archaeological Science of Sichuan University (23SASA01). We thank Prof. Etienne Patin and Prof. Lluis Quintana-Murci from the Human Evolutionary Genetics Unit of the Institute Pasteur for sharing the high-coverage genomes of 317 individuals from the Pacific region. We thank Prof. Mark Stoneking, Prof. Dang Liu at Max Planck Institute for Evolutionary Anthropology, and Prof. Wibhu Kutanan at Khon Kaen University for sharing genome-wide SNP data from Vietnam, Thailand, and Laos.

    摘要
  • 摘要: Tibeto-Burman (TB) people have endeavored to adapt to the hypoxic, cold, and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period. However, the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people, as well as their interaction mechanism, remain unknown. Here, we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity, admixture history, and differentiated adaptative features of geographically different TB-speaking people. We identify genetic differentiation related to geography and language among TB-speaking people, consistent with their differentiated admixture process with incoming or indigenous ancestral source populations. A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin hypothesis. We finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish speakers. Adaptative signatures associated with the physical pigmentation (EDAR and SLC24A5) and metabolism (ALDH9A1) are identified in Loloish people, which differed from the high-altitude adaptative genetic architecture in Tibetan. TB-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.
    Abstract: Tibeto-Burman (TB) people have endeavored to adapt to the hypoxic, cold, and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period. However, the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people, as well as their interaction mechanism, remain unknown. Here, we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity, admixture history, and differentiated adaptative features of geographically different TB-speaking people. We identify genetic differentiation related to geography and language among TB-speaking people, consistent with their differentiated admixture process with incoming or indigenous ancestral source populations. A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin hypothesis. We finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish speakers. Adaptative signatures associated with the physical pigmentation (EDAR and SLC24A5) and metabolism (ALDH9A1) are identified in Loloish people, which differed from the high-altitude adaptative genetic architecture in Tibetan. TB-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.
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出版历程
  • 收稿日期:  2023-08-25
  • 录用日期:  2023-10-04
  • 修回日期:  2023-09-28
  • 刊出日期:  2023-10-11

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