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Prospects for synthetic biology in 21st century agriculture

Xingyan Ye,  Kezhen Qin,  Alisdair R. Fernie,  Youjun Zhang

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文章导航 > Journal of Genetics and Genomics  > 2025 >  52(8): 967-986
Xingyan Ye, Kezhen Qin, Alisdair R. Fernie, Youjun Zhang. Prospects for synthetic biology in 21st century agriculture[J]. 遗传学报, 2025, 52(8): 967-986. doi: 10.1016/j.jgg.2024.12.016
引用本文: Xingyan Ye, Kezhen Qin, Alisdair R. Fernie, Youjun Zhang. Prospects for synthetic biology in 21st century agriculture[J]. 遗传学报, 2025, 52(8): 967-986. doi: 10.1016/j.jgg.2024.12.016
shu
Xingyan Ye, Kezhen Qin, Alisdair R. Fernie, Youjun Zhang. Prospects for synthetic biology in 21st century agriculture[J]. Journal of Genetics and Genomics, 2025, 52(8): 967-986. doi: 10.1016/j.jgg.2024.12.016
Citation: Xingyan Ye, Kezhen Qin, Alisdair R. Fernie, Youjun Zhang. Prospects for synthetic biology in 21st century agriculture[J]. Journal of Genetics and Genomics, 2025, 52(8): 967-986. doi: 10.1016/j.jgg.2024.12.016
shu

Prospects for synthetic biology in 21st century agriculture

doi: 10.1016/j.jgg.2024.12.016

  • a. Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;

  • b. College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;

  • c. Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany

基金项目: 

K.Z.Q, X.Y.Y, and Y.J.Z were supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Category B, XDB1090000). Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 are created with BioRender.com. We thank BioRender.

详细信息
    通讯作者:

    Alisdair R. Fernie,E-mail:Fernie@mpimp-golm.mpg.de

    Youjun Zhang,E-mail:yjzhang@genetics.ac.cn

Prospects for synthetic biology in 21st century agriculture

  • a. Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;

  • b. College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;

  • c. Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany

Funds: 

K.Z.Q, X.Y.Y, and Y.J.Z were supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Category B, XDB1090000). Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 are created with BioRender.com. We thank BioRender.

    摘要
  • 摘要: Plant synthetic biology has emerged as a transformative field in agriculture, offering innovative solutions to enhance food security, provide resilience to climate change, and transition to sustainable farming practices. By integrating advanced genetic tools, computational modeling, and systems biology, researchers can precisely modify plant genomes to enhance traits such as yield, stress tolerance, and nutrient use efficiency. The ability to design plants with specific characteristics tailored to diverse environmental conditions and agricultural needs holds great potential to address global food security challenges. Here, we highlight recent advancements and applications of plant synthetic biology in agriculture, focusing on key areas such as photosynthetic efficiency, nitrogen fixation, drought tolerance, pathogen resistance, nutrient use efficiency, biofortification, climate resilience, microbiology engineering, synthetic plant genomes, and the integration of artificial intelligence with synthetic biology. These innovations aim to maximize resource use efficiency, reduce reliance on external inputs, and mitigate environmental impacts associated with conventional agricultural practices. Despite challenges related to regulatory approval and public acceptance, the integration of synthetic biology in agriculture holds immense promise for creating more resilient and sustainable agricultural systems, contributing to global food security and environmental sustainability. Rigorous multi-field testing of these approaches will undoubtedly be required to ensure reproducibility.
    Abstract: Plant synthetic biology has emerged as a transformative field in agriculture, offering innovative solutions to enhance food security, provide resilience to climate change, and transition to sustainable farming practices. By integrating advanced genetic tools, computational modeling, and systems biology, researchers can precisely modify plant genomes to enhance traits such as yield, stress tolerance, and nutrient use efficiency. The ability to design plants with specific characteristics tailored to diverse environmental conditions and agricultural needs holds great potential to address global food security challenges. Here, we highlight recent advancements and applications of plant synthetic biology in agriculture, focusing on key areas such as photosynthetic efficiency, nitrogen fixation, drought tolerance, pathogen resistance, nutrient use efficiency, biofortification, climate resilience, microbiology engineering, synthetic plant genomes, and the integration of artificial intelligence with synthetic biology. These innovations aim to maximize resource use efficiency, reduce reliance on external inputs, and mitigate environmental impacts associated with conventional agricultural practices. Despite challenges related to regulatory approval and public acceptance, the integration of synthetic biology in agriculture holds immense promise for creating more resilient and sustainable agricultural systems, contributing to global food security and environmental sustainability. Rigorous multi-field testing of these approaches will undoubtedly be required to ensure reproducibility.
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  • 收稿日期:  2024-07-30
  • 录用日期:  2024-12-24
  • 修回日期:  2024-12-23
  • 刊出日期:  2024-12-30

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