Varying <i>Bifidobacterium</i> species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

Cong Liu; Qun Lu; Qi Xi; Shuxin Xiao; Jiangbo Du; Rui Qin; Jinghan Wang; Bo Xu; Xiumei Han; Kun Zhou; Shiyao Tao; Hong Lv; Yangqian Jiang; Tao Jiang; Kan Ye; Guangfu Jin; Hongxia Ma; Yankai Xia; Hongbing Shen; Xingyin Liu; Yuan Lin; Zhibin Hu

doi:10.1016/j.jgg.2025.01.015

文章导航 > Journal of Genetics and Genomics > 2025 > 优先出版

Cong Liu, Qun Lu, Qi Xi, Shuxin Xiao, Jiangbo Du, Rui Qin, Jinghan Wang, Bo Xu, Xiumei Han, Kun Zhou, Shiyao Tao, Hong Lv, Yangqian Jiang, Tao Jiang, Kan Ye, Guangfu Jin, Hongxia Ma, Yankai Xia, Hongbing Shen, Xingyin Liu, Yuan Lin, Zhibin Hu. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes[J]. 遗传学报. doi: 10.1016/j.jgg.2025.01.015

引用本文:

Cong Liu, Qun Lu, Qi Xi, Shuxin Xiao, Jiangbo Du, Rui Qin, Jinghan Wang, Bo Xu, Xiumei Han, Kun Zhou, Shiyao Tao, Hong Lv, Yangqian Jiang, Tao Jiang, Kan Ye, Guangfu Jin, Hongxia Ma, Yankai Xia, Hongbing Shen, Xingyin Liu, Yuan Lin, Zhibin Hu. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes[J]. 遗传学报. doi: 10.1016/j.jgg.2025.01.015

Citation:

Cong Liu, Qun Lu, Qi Xi, Shuxin Xiao, Jiangbo Du, Rui Qin, Jinghan Wang, Bo Xu, Xiumei Han, Kun Zhou, Shiyao Tao, Hong Lv, Yangqian Jiang, Tao Jiang, Kan Ye, Guangfu Jin, Hongxia Ma, Yankai Xia, Hongbing Shen, Xingyin Liu, Yuan Lin, Zhibin Hu. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2025.01.015

引用本文:

Cong Liu, Qun Lu, Qi Xi, Shuxin Xiao, Jiangbo Du, Rui Qin, Jinghan Wang, Bo Xu, Xiumei Han, Kun Zhou, Shiyao Tao, Hong Lv, Yangqian Jiang, Tao Jiang, Kan Ye, Guangfu Jin, Hongxia Ma, Yankai Xia, Hongbing Shen, Xingyin Liu, Yuan Lin, Zhibin Hu. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes[J]. 遗传学报. doi: 10.1016/j.jgg.2025.01.015

Citation:

Cong Liu, Qun Lu, Qi Xi, Shuxin Xiao, Jiangbo Du, Rui Qin, Jinghan Wang, Bo Xu, Xiumei Han, Kun Zhou, Shiyao Tao, Hong Lv, Yangqian Jiang, Tao Jiang, Kan Ye, Guangfu Jin, Hongxia Ma, Yankai Xia, Hongbing Shen, Xingyin Liu, Yuan Lin, Zhibin Hu. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2025.01.015

Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

doi: 10.1016/j.jgg.2025.01.015

Cong Liu^a,b,
Qun Lu^a,c,d,
Qi Xi^e,
Shuxin Xiao^a,c,
Jiangbo Du^a,b,f,
Rui Qin^a,g,
Jinghan Wang^a,c,
Bo Xu^a,b,
Xiumei Han^a,b,
Kun Zhou^a,b,
Shiyao Tao^a,
Hong Lv^a,c,f,
Yangqian Jiang^a,c,
Tao Jiang^a,h,
Kan Yeⁱ,
Guangfu Jin^a,b,f,
Hongxia Ma^a,b,f,
Yankai Xia^a,j,
Hongbing Shen^a,b,f,
Xingyin Liu^a, ,,
Yuan Lin^a,c,f, ,,
Zhibin Hu^a,b,f, ,

a. State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
b. Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
c. Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
d. Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu 210004, China;
e. Department of Obstetrics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China;
f. State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China;
g. Scientific Research and Education Department, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu 213000, China;
h. Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
i. Department of Child Health Care, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China;
j. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China

基金项目:

it was their contributions that made this study possible. C.L., Q.L., and Q.X. contributed equally to this work. This work was supported by grants from the National Key Research and Development Program of China (2022YFA1303900, 2021YFC2700705), and the National Natural Science Foundation of China (82103919). The funding sources had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

We would like to thank the well-dedicated women and staff who participated in this cohort study

详细信息

通讯作者:
Xingyin Liu,E-mail:xingyinliu@njmu.edu.cn

Yuan Lin,E-mail:yuanlin@njmu.edu.cn

Zhibin Hu,E-mail:zhibin_hu@njmu.edu.cn

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出版历程
- 收稿日期: 2025-01-16
- 录用日期: 2025-01-19
- 网络出版日期: 2025-07-11

Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

Cong Liu^a,b,
Qun Lu^a,c,d,
Qi Xi^e,
Shuxin Xiao^a,c,
Jiangbo Du^a,b,f,
Rui Qin^a,g,
Jinghan Wang^a,c,
Bo Xu^a,b,
Xiumei Han^a,b,
Kun Zhou^a,b,
Shiyao Tao^a,
Hong Lv^a,c,f,
Yangqian Jiang^a,c,
Tao Jiang^a,h,
Kan Yeⁱ,
Guangfu Jin^a,b,f,
Hongxia Ma^a,b,f,
Yankai Xia^a,j,
Hongbing Shen^a,b,f,
Xingyin Liu^{a
, ,},
Yuan Lin^{a,c,f
, ,},
Zhibin Hu^{a,b,f
, ,}

a. State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
b. Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
c. Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
d. Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu 210004, China;
e. Department of Obstetrics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China;
f. State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China;
g. Scientific Research and Education Department, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu 213000, China;
h. Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
i. Department of Child Health Care, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China;
j. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China

Funds:

We would like to thank the well-dedicated women and staff who participated in this cohort study

摘要

摘要:
The impact of mother-infant microbiota on neurodevelopment is an area of interest, but longitudinal studies are scarce. Using a cohort of 520 families from the Jiangsu birth cohort in China, we reveal that the maternal gut microbiota during early pregnancy play a substantial role, accounting for 3.34% of the variance in offspring neurodevelopmental scores. This contribution is notably higher than the 1.24% attributed to the infants’ own microbiota at 1 year of age, underscoring the significant influence of maternal gut health on early child development. Remarkably, an elevation in maternal Bifidobacterium pseudocatenulatum is linked to decreased cognitive scores, whereas an enrichment of Bifidobacterium longum at 1 year of age is associated with higher cognitive scores. Furthermore, we find that maternal B. pseudocatenulatum is linked to the heterolactic fermentation metabolic pathway, while infant B. longum is associated with the Bifidobacterium shunt pathway. In summary, our analysis implies that maternal and infant gut microbiota play a distinct role in neurodevelopment, suggesting potential strategies for improving neurodevelopmental outcomes during early pregnancy or infant development by targeting gut microbiota composition.
- Gut microbiota /
- Neurodevelopment /
- Bifidobacterium /
- Pregnancy /
- Cohort study
Abstract:
The impact of mother-infant microbiota on neurodevelopment is an area of interest, but longitudinal studies are scarce. Using a cohort of 520 families from the Jiangsu birth cohort in China, we reveal that the maternal gut microbiota during early pregnancy play a substantial role, accounting for 3.34% of the variance in offspring neurodevelopmental scores. This contribution is notably higher than the 1.24% attributed to the infants’ own microbiota at 1 year of age, underscoring the significant influence of maternal gut health on early child development. Remarkably, an elevation in maternal Bifidobacterium pseudocatenulatum is linked to decreased cognitive scores, whereas an enrichment of Bifidobacterium longum at 1 year of age is associated with higher cognitive scores. Furthermore, we find that maternal B. pseudocatenulatum is linked to the heterolactic fermentation metabolic pathway, while infant B. longum is associated with the Bifidobacterium shunt pathway. In summary, our analysis implies that maternal and infant gut microbiota play a distinct role in neurodevelopment, suggesting potential strategies for improving neurodevelopmental outcomes during early pregnancy or infant development by targeting gut microbiota composition.
- Gut microbiota /
- Neurodevelopment /
- Bifidobacterium /
- Pregnancy /
- Cohort study

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Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

doi: 10.1016/j.jgg.2025.01.015

通讯作者:
Xingyin Liu,E-mail:xingyinliu@njmu.edu.cn

Yuan Lin,E-mail:yuanlin@njmu.edu.cn

Zhibin Hu,E-mail:zhibin_hu@njmu.edu.cn

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Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

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Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

doi: 10.1016/j.jgg.2025.01.015

通讯作者: Xingyin Liu,E-mail:xingyinliu@njmu.edu.cn Yuan Lin,E-mail:yuanlin@njmu.edu.cn Zhibin Hu,E-mail:zhibin_hu@njmu.edu.cn

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Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

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出版历程

目录

通讯作者:
Xingyin Liu,E-mail:xingyinliu@njmu.edu.cn

Yuan Lin,E-mail:yuanlin@njmu.edu.cn

Zhibin Hu,E-mail:zhibin_hu@njmu.edu.cn