留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors

Jiangtao Chen Wen Tu Ziqi Li Mingze Ma Simei Jiang Wenyue Guan Rong Wang Yufeng Pan Qionglin Peng

Jiangtao Chen, Wen Tu, Ziqi Li, Mingze Ma, Simei Jiang, Wenyue Guan, Rong Wang, Yufeng Pan, Qionglin Peng. Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors[J]. 遗传学报. doi: 10.1016/j.jgg.2025.02.005
引用本文: Jiangtao Chen, Wen Tu, Ziqi Li, Mingze Ma, Simei Jiang, Wenyue Guan, Rong Wang, Yufeng Pan, Qionglin Peng. Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors[J]. 遗传学报. doi: 10.1016/j.jgg.2025.02.005
Jiangtao Chen, Wen Tu, Ziqi Li, Mingze Ma, Simei Jiang, Wenyue Guan, Rong Wang, Yufeng Pan, Qionglin Peng. Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2025.02.005
Citation: Jiangtao Chen, Wen Tu, Ziqi Li, Mingze Ma, Simei Jiang, Wenyue Guan, Rong Wang, Yufeng Pan, Qionglin Peng. Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors[J]. Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2025.02.005

Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors

doi: 10.1016/j.jgg.2025.02.005
基金项目: 

We thank the Bloomington Drosophila Stock Center for providing the fly stocks. This work was supported by the National Key R&D Program of China (2021YFA1101300), the National Natural Science Foundation of China (32371067 to Y.P.), the Natural Science Foundation from Jiangsu Province (BK20231418 to Q.P.), and the Fundamental Research Funds for the Central Universities (2242023R40054 to Q.P.).

详细信息
    通讯作者:

    Yufeng Pan,E-mail:pany@seu.edu.cn

    Qionglin Peng,E-mail:pengqionglin@seu.edu.cn

Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors

Funds: 

We thank the Bloomington Drosophila Stock Center for providing the fly stocks. This work was supported by the National Key R&D Program of China (2021YFA1101300), the National Natural Science Foundation of China (32371067 to Y.P.), the Natural Science Foundation from Jiangsu Province (BK20231418 to Q.P.), and the Fundamental Research Funds for the Central Universities (2242023R40054 to Q.P.).

  • 摘要:

    Sex-specific neurons play pivotal roles in regulating sexually dimorphic behaviors. In insects, the sex determination gene doublesex (dsx) establishes major sexual dimorphism of the nervous system, in which male-specific dsxM promotes neuronal development, while female-specific dsxF inhibits neuronal development by promoting neuronal apoptosis. In this study, we find that dsx regulates the number of dsx-expressing central neurons in Drosophila in cell-specific manners. Although dsxM overall promotes an increase in the number of dsx neurons, it inhibits the emergence of specific pC1 neurons. dsxF reduces the number of different pC1/pC2 subtypes, but promotes the formation of pC1d. We also find that dsxM and dsxF barely affect the number of some pC2 neurons. Changes in the number of pC1/pC2 neuron numbers alter their roles in regulating different behaviors, including courtship, aggression, and locomotion. Our results illustrate the multifaceted functions of dsx in sexually dimorphic neuronal development and behaviors.

  • 加载中
计量
  • 文章访问数:  5
  • HTML全文浏览量:  2
  • PDF下载量:  0
  • 被引次数: 0
出版历程
  • 收稿日期:  2024-10-28
  • 录用日期:  2025-02-13
  • 修回日期:  2025-02-13
  • 网络出版日期:  2025-07-11

目录

    /

    返回文章
    返回