IGF-1-mediated upregulation of gut <i>Blautia</i> correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

Zekun Deng; Siyu Chen; Yong She; Yunzhi Zou; Zeming Yan; Jintong Cheng; Guanghao Yue; Depei Li; Qi Zhao; Xia Zhao; Xiaobing Jiang

doi:10.1016/j.jgg.2025.04.015

IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

doi: 10.1016/j.jgg.2025.04.015

1. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
2. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China;
3. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
4. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China;
5. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
6. Department of Microbiology, Army Medical University, Chongqing 400038, China;
7. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China

基金项目:

This study was supported by the National Natural Science Foundation of China (82372624 to X.J.), and Guangdong Basic and Applied Basic Research Foundation (2024A1515013102 and 2022A1515012430 to X.J.). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

详细信息

通讯作者:
Qi Zhao,E-mail:zhaoqi@sysucc.org.cn

Xia Zhao,E-mail:zhaoxia1@sysucc.org.cn

Xiaobing Jiang,E-mail:jiangxiaob1@sysucc.org.cn

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出版历程
- 收稿日期: 2024-11-11
- 录用日期: 2025-04-25
- 修回日期: 2025-04-23
- 刊出日期: 2025-05-02

IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

1. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
2. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China;
3. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
4. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China;
5. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
6. Department of Microbiology, Army Medical University, Chongqing 400038, China;
7. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China

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Chen, T., Chen, X., Zhang, S., Zhu, J., Tang, B., Wang, A., Dong, L., Zhang, Z., Yu, C., Sun, Y., et al., 2021. The Genome Sequence Archive family: toward explosive data growth and diverse data types. Genomics Proteomics Bioinformatics19, 578-583.

Cheverud, James, M., 1999. Genetics and analysis of quantitative traits. Am. J. Phys. Anthropol. 108, 548-549.

CNCB-NGDC Members and Partners, 2022. Database resources of the national genomics data center, China national center for bioinformation in 2022. Nucleic Acids Res. 50, D27-D38.

Elhanani, O., Ben-Uri, R.,Keren, L., et al., 2023. Spatial profiling technologies illuminate the tumor microenvironment. Cancer Cell 41, 404-420.

Farzi, A., Frohlich, E.E., iety for Holzer, P., et al., 2018. Gut Microbiota and the Neuroendocrine System. Neurotherapeutics 15, 5-22.

Feng, J., Duan, Z., Yao, K., Gui, Q., Liu, X., Wang, X., Du, Z., Shao, L., Zhang, B., Cai, S., et al., 2023. Primary papillary epithelial tumor of the sella and posterior pituitary tumor show similar (epi)genetic features and constitute a single neuro-oncological entity. Neuro. Oncol. 25, 1487-1497.

Fridlender, Z.G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L., Worthen, G.S.,Albelda, S.M., et al., 2009. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16, 183-194.

Hases, L., Stepanauskaite, L., Birgersson, M., Brusselaers, N., Schuppe-Koistinen, I., Archer, A., Engstrand, L.,Williams, C., et al., 2023. High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice. Commun. Biol. 6, 20.

Hoshida, S., Kuzuya, T., Fuji, H., Oe, H., Hori, M., Kamada, T.,Tada, M., et al., 1993. Transcardiac alteration of neutrophil function relates to myocardial ischaemia/reperfusion injury. Cardiovasc. Res. 27, 377-383.

Hosomi, K., Saito, M., Park, J., Murakami, H., Shibata, N., Ando, M., Nagatake, T., Konishi, K., Ohno, H., Tanisawa, K., et al., 2022. Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Nat. Commun. 13, 4477.

Loi, S., Drubay, D., Adams, S., Pruneri, G., Francis, P.A., Lacroix-Triki, M., Joensuu, H., Dieci, M.V., Badve, S., Demaria, S., et al., 2019. Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers. J. Clin. Oncol. 37, 559-569.

Piccard, H., Muschel, R.J.,Opdenakker, G., et al., 2012. On the dual roles and polarized phenotypes of neutrophils in tumor development and progression. Crit. Rev. Oncol. Hematol. 82, 296-309.

Qiu, D.,Sun, S., 2024. Causal relationships between immunophenotypes, plasma metabolites, and temporomandibular disorders based on Mendelian randomization. Sci. Rep. 14, 22262.

Shibata, M., Ozato, N., Tsuda, H., Mori, K., Kinoshita, K., Katashima, M., Katsuragi, Y., Nakaji, S.,Maeda, H., et al., 2023. Mouse model of anti-obesity effects of Blautia hansenii on diet-induced obesity. Curr. Issues. Mol. Biol. 45, 7147-7160.

Stols-Goncalves, D., Mak, A.L., Madsen, M.S., van der Vossen, E.W.J., Bruinstroop, E., Henneman, P., Mol, F., Scheithauer, T.P.M., Smits, L., Witjes, J., et al., 2023. Faecal Microbiota transplantation affects liver DNA methylation in non-alcoholic fatty liver disease: a multi-omics approach. Gut Microbes 15, 2223330.

Suhre, K., Dadhania, D.M., Lee, J.R., Muthukumar, T., Chen, Q., Gross, S.S.,Suthanthiran, M., et al., 2021. Kidney allograft function is a confounder of urine metabolite profiles in kidney allograft recipients. Metabolites 11, 533.

Suhre, K., Schwartz, J.E., Sharma, V.K., Chen, Q., Lee, J.R., Muthukumar, T., Dadhania, D.M., Ding, R., Ikle, D.N., Bridges, N.D., et al., 2016. Urine metabolite profiles predictive of human kidney allograft status. J. Am. Soc. Nephrol. JASN 27, 626-636.

Ugel, S., Cane, S., De Sanctis, F.,Bronte, V., et al., 2021. Monocytes in the tumor microenvironment. Annu. Rev. Pathol. 16, 93-122.

Wang, Y., Spatz, M., Da Costa, G., Michaudel, C., Lapiere, A., Danne, C., Agus, A., Michel, M.L., Netea, M.G., Langella, P., et al., 2022. Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice. Microbiome 10, 91.

Xiong, Q., Huang, Z., Xin, L., Qin, B., Zhao, X., Zhang, J., Shi, W., Yang, B., Zhang, G.,Hu, Y., et al., 2021. Post-treatment neutrophil-to-lymphocyte ratio (NLR) predicts response to anti-PD-1/PD-L1 antibody in SCLC patients at early phase. Cancer Immunol. Immunother. CII 70, 713-720.

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IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

doi: 10.1016/j.jgg.2025.04.015

通讯作者:
Qi Zhao,E-mail:zhaoqi@sysucc.org.cn

Xia Zhao,E-mail:zhaoxia1@sysucc.org.cn

Xiaobing Jiang,E-mail:jiangxiaob1@sysucc.org.cn

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IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

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留言板

IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

doi: 10.1016/j.jgg.2025.04.015

通讯作者: Qi Zhao,E-mail:zhaoqi@sysucc.org.cn Xia Zhao,E-mail:zhaoxia1@sysucc.org.cn Xiaobing Jiang,E-mail:jiangxiaob1@sysucc.org.cn

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出版历程

IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

计量

出版历程

目录

通讯作者:
Qi Zhao,E-mail:zhaoqi@sysucc.org.cn

Xia Zhao,E-mail:zhaoxia1@sysucc.org.cn

Xiaobing Jiang,E-mail:jiangxiaob1@sysucc.org.cn