Journal of Genetics and Genomics

Molecular insights into the transgenerational inheritance of stress memory

Qian Zhang, Ye Tian

2022, 49(2): 89-95. doi: 10.1016/j.jgg.2021.11.015

Abstract (327) PDF (28)

Abstract:
There is accumulating evidence to show that environmental stressors can regulate a variety of phenotypes in descendants through germline-mediated epigenetic inheritance. Studies of model organisms exposed to environmental cues (e.g., diet, heat stress, toxins) indicate that altered DNA methylations,...

The quantitative proteome atlas of a model cyanobacterium

Jinlong Wang, Xiahe Huang, Haitao Ge, Yan Wang, Weiyang Chen, Limin Zheng, Chengcheng Huang, Haomeng Yang, Lingyu Li, Na Sui, Yu Wang, Yuanya Zhang, Dandan Lu, Longfa Fang, Wu Xu, Yuqiang Jiang, Fang Huang, Yingchun Wang

2022, 49(2): 96-108. doi: 10.1016/j.jgg.2021.09.007

Abstract (223) PDF (27)

Abstract:
Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations of the majority of proteins in any cyanobacteria remain undetermined, representing a major challeng...

Phylogeny and sex chromosome evolution of Palaeognathae

Zongji Wang, Jilin Zhang, Xiaoman Xu, Christopher Witt, Yuan Deng, Guangji Chen, Guanliang Meng, Shaohong Feng, Luohao Xu, Tamas Szekely, Guojie Zhang, Qi Zhou

2022, 49(2): 109-119. doi: 10.1016/j.jgg.2021.06.013

Abstract (243) HTML PDF (27)

Abstract:
Many paleognaths (ratites and tinamous) have a pair of homomorphic ZW sex chromosomes in contrast to the highly differentiated sex chromosomes of most other birds. To understand the evolutionary causes for the different tempos of sex chromosome evolution, we produced female genomes of 12 paleognatho...

The Melastoma dodecandrum genome and the evolution of Myrtales

Yang Hao, Yu-Zhen Zhou, Bin Chen, Gui-Zhen Chen, Zhen-Ying Wen, Diyang Zhang, Wei-Hong Sun, Ding-Kun Liu, Jie Huang, Jin-Liao Chen, Xiao-Qin Zhou, Wan-Lin Fan, Wen-Chun Zhang, Lin Luo, Wen-Chao Han, Yan Zheng, Long Li, Peng-Cheng Lu, Yue Xing, Shu-Ya Liu, Jia-Ting Sun, Ying-Hui Cao, Yan-Ping Zhang, Xiao-Ling Shi, Sha-Sha Wu, Ye Ai, Jun-Wen Zhai, Si-Ren Lan, Zhong-Jian Liu, Dong-Hui Peng

2022, 49(2): 120-131. doi: 10.1016/j.jgg.2021.10.004

Abstract (446) PDF (53)

Abstract:
Melastomataceae has abundant morphological diversity with high economic and ornamental merit in Myrtales. The phylogenetic position of Myrtales is still contested. Here, we report the chromosome-level genome assembly of Melastoma dodecandrum in Melastomataceae. The assembled genome size is 299.81Mb ...

Aberrant nuclear lamina contributes to the malignancy of human gliomas

Shunqi Pei, Xuehui Wang, Xuan Wang, Hao Huang, Huaping Tao, Binghua Xie, Aifen Yang, Mengsheng Qiu, Zhou Tan

2022, 49(2): 132-144. doi: 10.1016/j.jgg.2021.08.013

Abstract (234) PDF (14)

Abstract:
Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the malignant progress of gliomas. By virtue of integrated proteomics and genomics analyses...

Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism

Lu Wang, Jinchen Li, Chan Wang, Ruqi Tang, Jialong Liang, Yuhua Gong, Yaping Dai, Ningling Ding, Jian Wu, Na Dai, Lei Liu, Yi Zhao, Youlin Shao, Weifeng Zhao, Peng Jiang, Xingjuan Shi, Weichang Chen, Ye Tian, Xiangdong Liu, Xiong Ma, Zhongsheng Sun

2022, 49(2): 145-154. doi: 10.1016/j.jgg.2021.07.019

Abstract (234) PDF (16)

Abstract:
Primary biliary cholangitis (PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutation...

The role of genotype and diet in shaping gut microbiome in a genetic vitamin A deficient mouse model

Jun Xu, Jie-Ni Zhang, Bo-Hui Sun, Qing Liu, Juan Ma, Qian Zhang, Yong-Xin Liu, Ning Chen, Feng Chen

2022, 49(2): 155-164. doi: 10.1016/j.jgg.2021.08.015

Abstract (268) PDF (24)

Abstract:
Multifactors have been reported to affect the gut microbiome, including genotype, age, diet, and nutrition. However, few reports have investigated the relative capacity of different factors to shape the gut microbiome in a single study. Our design used a genetic vitamin A-deficient mouse model, the ...

The sex determination gene doublesex is required during adulthood to maintain sexual orientation

Qionglin Peng, Jiangtao Chen, Xiangbin Su, Rong Wang, Caihong Han, Yufeng Pan

2022, 49(2): 165-168. doi: 10.1016/j.jgg.2021.08.006

Abstract (330) PDF (31)

Abstract:

Identification of CHMP4C as a new risk gene for inherited dilated cardiomyopathy

Nianwei Zhou, Lu Tang, Yingying Jiang, Xuejie Li, Shifang Shan, Bo Yuan, Shengmei Qin, Cuizhen Pan, Xiaolin Wang, Xianhong Shu, Zilong Qiu, Junbo Ge

2022, 49(2): 169-172. doi: 10.1016/j.jgg.2021.08.014

Abstract (207) PDF (25)

Abstract:

Transcriptional memory of different types of genes is generally maintained under various environmental conditions in Saccharomyces cerevisiae

Ru-Xin Wang, Yu-Min Li, Runfa Chen, Hai-Ning Du

2022, 49(2): 173-176. doi: 10.1016/j.jgg.2021.10.007

Abstract (317) PDF (48)

Abstract:

Genome-wide meta-analysis identifies ten new psoriasis susceptibility loci in the Chinese population

Weiwei Chen, Wenjun Wang, Liang Yong, Qi Zhen, Yafen Yu, Huiyao Ge, Yiwen Mao, Lu Cao, Ruixue Zhang, Xia Hu, Zhuo Li, Yirui Wang, Wencheng Fan, Qiongqiong Xu, Hui Zhang, Shirui Chen, Jing Wu, Liangdan Sun

2022, 49(2): 177-180. doi: 10.1016/j.jgg.2021.10.001

Abstract (146) PDF (20)

Abstract:

2022 Vol. 49, No. 2