Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions

Tiantian Ma; Feng Zhang; Yaqing Wang; Zhiheng Xu

doi:10.1016/j.jgg.2022.04.001

Volume 49 Issue 6

Jun. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(6): 519-522

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Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions

doi: 10.1016/j.jgg.2022.04.001

a. Center for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
b. University of Chinese Academy of Sciences, Beijing 100049, China

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Due to the word limit, many studies cannot be cited, and we are deeply sorry. This work was supported by grants from the National Natural Science Foundation of China (91854118, 31921002, 31730108, 32061143026), the major projects of the Ministry of Science and Technology (2021ZD0202300), and Chinese Academy of Sciences (XDB32020100, YJKYYQ20200052).

Received Date: 2022-02-17
Revised Date: 2022-04-06
Accepted Date: 2022-04-06
Publish Date: 2022-06-30

Abstract

Abstract

Coat protein complex II (COPII)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum (ER) to different destinations. cTAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPII carrier and cargo trafficking through direct or indirect interaction with COPII components. cTAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions.
- cTAGE5/MEA6,
- COPII,
- ER,
- Cargo secretion

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References(20)

References

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