A dog carrying mutations in <i>AVP-NPII</i> exhibits key features of central diabetes insipidus

Huijuan Xu; Haiyang Hao; Shirui Wang; Xueru Liu; Wen Lyu; Zhentao Zuo; Yan Zhuo; Jidong Mi; Yong Q. Zhang; Rui Tian; Huijuan Zhu

doi:10.1016/j.jgg.2022.11.003

Volume 50 Issue 4

Apr. 2023

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A dog carrying mutations in AVP-NPII exhibits key features of central diabetes insipidus

doi: 10.1016/j.jgg.2022.11.003

Huijuan Xu^1,2,
Haiyang Hao³,
Shirui Wang¹⁶,
Xueru Liu^18,19,
Wen Lyu^4,5,
Zhentao Zuo^6,7,8,
Yan Zhuo⁹,
Jidong Mi¹⁰,
Yong Q. Zhang^13,14,
Rui Tian¹¹,
Huijuan Zhu¹²

1. State Key Laboratory for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
3. Beijing Sinogene Biotechnology Co. Ltd, Beijing 100005, China;
4. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
5. State Key Laboratory for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
6. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
7. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
8. Hefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, Anhui 230088, China;
9. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
10. Beijing Sinogene Biotechnology Co. Ltd, Beijing 100005, China;
11. State Key Laboratory for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
12. Department of Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China;
13. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
14. State Key Laboratory for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
16. Department of Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China;
18. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
19. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Funds:

We thank Hui Zhao and Yi Ding for discussion, Liang Wu, Qiqi Wang, and Junzheng Shi for assistance in experiments. This work was supported by grants from the National Key Research and Development Program (2019YFA0707100 and 2021ZD0203901 to Y.Q. Zhang and R. Tian), the Strategic Priority Research Program B of the Chinese Academy of Sciences (XDBS1020100 to Y.Q. Zhang), the National Science Foundation of China (31830036 and 31921002 to Y.Q. Zhang).

Received Date: 2022-08-25
Accepted Date: 2022-11-02
Rev Recd Date: 2022-11-02
Publish Date: 2023-04-30

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References

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A dog carrying mutations in AVP-NPII exhibits key features of central diabetes insipidus

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