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Volume 52 Issue 1
Jan.  2025
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Article Navigation >  Journal of Genetics and Genomics  > 2025  >  52(1): 24-38

The interplay between histone modifications and nuclear lamina in genome regulation

doi: 10.1016/j.jgg.2024.10.005
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    a. Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen 518132, China;

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    b. Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain;

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    c. Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;

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    d. School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China;

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    e. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University, Chongqing 400030, China

Funds:

Shenzhen Bay Laboratory Joint Optical Microscopic Imaging Technology Development Program (S234602004-1 to Q.P.). We acknowledge the usage of BioRender (https://www.biorender.com/) for creating the figures.

This work was financially supported by the National Natural Science Foundation of China (32100450 and 32471370 to Q.P., 12372302 to J.Q.), the Guangdong Pearl River Talent Program (2021QN02Y781 to Q.P.), and the Evident &

  • Received Date: 2024-06-19
  • Accepted Date: 2024-10-09
  • Rev Recd Date: 2024-10-08
    • Available Online: 2025-07-11
  • Publish Date: 2024-10-18
    Abstract
  • Gene expression is regulated by chromatin architecture and epigenetic remodeling in cell homeostasis and pathologies. Histone modifications act as the key factors to modulate the chromatin accessibility. Different histone modifications are strongly associated with the localization of chromatin. Heterochromatin primarily localizes at the nuclear periphery, where it interacts with lamina proteins to suppress gene expression. In this review, we summarize the potential bridges that have regulatory functions of histone modifications in chromatin organization and transcriptional regulation at the nuclear periphery. We use lamina-associated domains (LADs) as examples to elucidate the biological roles of the interactions between histone modifications and nuclear lamina in cell differentiation and development. In the end, we highlight the technologies that are currently used to identify and visualize histone modifications and LADs, which could provide spatiotemporal information for understanding their regulatory functions in gene expression and discovering new targets for diseases.
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