Revealing extensive inbreeding and less efficient purging of deleterious mutations in wild Amur tigers in China

doi: 10.1016/j.jgg.2024.12.004

• Tianming Lan ^a,b , 
• Haimeng Li ^a,c,d , 
• Boyang Liu ^a , 
• Minhui Shi ^c , 
• Yinping Tian ^a , 
• Sunil Kumar Sahu ^e , 
• Liangyu Cui ^a , 
• Nicolas Dussex ^f,g,h , 
• Dan Liu ⁱ , 
• Yue Ma ^a , 
• Weiyao Kong ^j , 
• Shanlin Liu ^k , 
• Jiale Fan ^a , 
• Yue Zhao ^a , 
• Yuan Fu ^a , 
• Qiye Li ^c , 
• Chen Lin ^a , 
• Love Dalén ^f,g,h , 
• Huan Liu ^b,c,l , 
• Le Zhang ^a     , 
• Guangshun Jiang ^a     , 
• Yanchun Xu ^a,b,m    

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  a. College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang 150040, China;

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  b. BGI Life Science Joint Research Center, Northeast Forestry University, Harbin, Heilongjiang 150040, China;

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  c. State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, Guangdong 518083, China;

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  d. Heilongjiang Key Laboratory of Complex Traits and Protein Machines in Organisms, Harbin, Heilongjiang 150040, China;

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  e. BGI Research, Wuhan, Hubei 430074, China;

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  f. Centre for Palaeogenetics, Svante Arrhenius väg 20C, 10691 Stockholm, Sweden;

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  g. Department of Zoology, Stockholm University, Stockholm, Sweden;

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  h. Department of Bioinformatics and Genetics, Swedish Museum of Natural History, Stockholm, Sweden;

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  i. Heilongjiang Siberian Tiger Park, Harbin, Heilongjiang 150000, China;

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  j. Jinlin Provincial Academy of Forestry Science, Changchun, Jilin 130033, China;

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  k. Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;

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  l. Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, Guangdong 518120, China;

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  m. National Forestry and Grassland Administration Research Center of Engineering Technology for Wildlife Conservation and Utilization, Harbin, Heilongjiang 150040, China