Neutrophils disrupt the intestinal barrier via IL-22/TGF-β/Mmp9 axis in the zebrafish model of inflammatory bowel disease

Peixian Huang; Yiqing Yang; Junwei Lian; Tao Yu; Gaofei Li; Yiyue Zhang

doi:10.1016/j.jgg.2025.04.012

Volume 52 Issue 7

Jul. 2025

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Neutrophils disrupt the intestinal barrier via IL-22/TGF-β/Mmp9 axis in the zebrafish model of inflammatory bowel disease

doi: 10.1016/j.jgg.2025.04.012

1. Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China;
2. Department of Intensive Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), School of Medicine, South China University of Technology, Guangzhou, Guangdong 510080, China;
3. Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China;
4. The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China;
5. Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, China;
6. Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China;
7. Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China;
8. Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China;
9. Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China;
10. The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China

Funds:

We thank all the staff at the research platform and zebrafish facility of SCUT. This work is supported by the National Key R&D Program of China (2023YFA1800100 and 2024YFF1206600), the National Natural Science Foundation of China (32100664), and the Basic and Applied Basic Research Foundation of Guangdong Province (2024B1515040019 and 2022A1515012042).

Received Date: 2024-11-20
Accepted Date: 2025-04-17
Rev Recd Date: 2025-04-17

Available Online: 2025-07-11

Publish Date: 2025-04-25

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