E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

Xianping Wang; Yifan Guo; Chenglong Wang; Jingjie Mu; Xianjue Ma

doi:10.1016/j.jgg.2025.10.006

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E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy

doi: 10.1016/j.jgg.2025.10.006

a. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China;
b. State Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China;
c. Central Laboratory of Science and Technology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Funds:

This project was supported by the National Natural Science Foundation of China (32170824, 32322027 to X.M.), HRHI program of Westlake Laboratory of Life Sciences and Biomedicine (1011103360222B1 to X.M.), "Pioneer" and "Leading Goose" R&

D Program of Zhejiang (2024SSYS0034), and State Key Laboratory of Gene Expression.

Received Date: 2025-07-06
Accepted Date: 2025-10-26
Rev Recd Date: 2025-10-23

Available Online: 2025-11-03

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References

Ahmed, S.M.H., Maldera, J.A., Krunic,D., Paiva-Silva, G.O., Penalva, C., Teleman, A.A., Edgar, B.A., 2020. Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila. Nature 584, 415-419.

Bialecki, M., Shilton, A., Fichtenberg, C., Segraves, W.A., Thummel, C.S., 2002. Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila. Dev. Cell 3, 209-220.

Brutscher, F.G.F., Hausmann, G., Jutz, L., Basler, K., 2025. Activation of the Drosophila innate immune system accelerates growth in cooperation with oncogenic Ras. PLoS Biol. 23, e3003068.

Dillard, C., Teles-Reis, J., Jain, A., Antunes, M.G., Ruiz-Duran, P., Qi, Y., Le Borgne, R., Jasper, H., Rusten, T.E., 2025. NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. PLoS Biol. 23, e3002663.

Griffin, P., Dimitry, J.M., Sheehan, P.W., Lananna, B.V., Guo, C., Robinette, M.L., Hayes, M. E., Cedeno, M.R., Nadarajah, C.J., Ezerskiy, L.A., et al., 2019. Circadian clock protein Rev-erbα regulates neuroinflammation. Proc. Natl. Acad. Sci. U. S. A. 116, 5102-5107.

Guo, D.K., Zhu, Y., Sun, H.Y., Xu, X.Y., Zhang, S., Hao, Z.B., Wang, G.H., Mu, C.C., Ren, H.G., 2019. Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway. Acta Pharmacol. Sin. 40, 26-34.

Hariharan, I.K., Bilder, D., 2006. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu. Rev. Genet. 40, 335-361.

Ji, S.M., and Hoffmann, J.A., 2024. Toll-9 prevents the proliferation of injected oncogenic cells in adult flies. J. Genet. Genomics 51, 1331-1333.

Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M., Hoffmann, J. A., 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.

Nussleinvolhard, C., Wieschaus, E., 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.

Reinking, J., Lam, M.M., Pardee, K., Sampson, H.M., Liu, S., Yang, P., Williams, S., White, W., Lajoie, G., Edwards, A., et al., 2005. The Drosophila nuclear receptor E75 contains heme and is gas responsive. Cell 122, 195-207.

Valanne, S., Wang, J.H., Ramet, M., 2011. The Drosophila Toll signaling pathway. J. Immunol. 186, 649-656.

Wang, X.P., Guo, Y.F., Lin, P., Yu, M., Song, S., Xu, W.Y., Kong, D., Wang, Y., Zhang, Y.X., Lu, F., et al., 2024. Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways. EMBO J. 43, 6336-6363.

Wang, X.P., Wang, H., Liu, L., Li, S., Emery, G., Chen, J., 2020. Temporal coordination of collective migration and lumen formation by antagonism between two nuclear receptors. iScience 23, 101335.

Zhao, S., Guo, Y., Kuang, X., Li, X., Wu, C., Lin, P., Xie, Q., Zhai, Z., Kong, D., Ma, X., 2025. Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila. EMBO J. 44, 5394-5428.

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