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Volume 51 Issue 2
Feb.  2024
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Article Navigation >  Journal of Genetics and Genomics  > 2024  >  51(2): 159-183

Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment

doi: 10.1016/j.jgg.2023.07.007
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    a. MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China;

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    b. Center for Reproductive Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

Funds:

This work was supported by the National Natural Science Foundation (32001063 and 82201769), the Guangdong Special Support Program (2019BT02Y276), the Guangdong Basic and Applied Basic Research Foundation (2021A1515010759 and 2023A1515010176), the grant from MOE Key Laboratory of Gene Function and Regulation, the Guangzhou Science and Technology Planning Project (202201020411 and 2023A04J1952), and the Fundamental Research Funds for the Central Universities, Sun Yat-sen University (23ptpy59).

  • Received Date: 2023-03-29
  • Accepted Date: 2023-07-15
  • Rev Recd Date: 2023-07-13
  • Publish Date: 2023-07-27
    Abstract
  • Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide, causing pain, disability, and decreased quality of life. The balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of OA. Currently, there is a lack of effective therapeutic strategies for OA treatment. With the development of CRISPR-based genome, epigenome, and RNA editing tools, OA treatment has been improved by targeting genetic risk factors, activating chondrogenic elements, and modulating inflammatory regulators. Supported by cell therapy and in vivo delivery vectors, genome, epigenome, and RNA editing tools may provide a promising approach for personalized OA therapy. This review summarizes CRISPR-based genome, epigenome, and RNA editing tools that can be applied to the treatment of OA and provides insights into the development of CRISPR-based therapeutics for OA treatment. Moreover, in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.
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