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Article Navigation >  Journal of Genetics and Genomics  > 2023  > Accepted Manuscript

Unraveling the complexity of polycystic ovary syndrome with animal models

doi: 10.1016/j.jgg.2023.09.012
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    a Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China;

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    b Key Laboratory of Women's Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China;

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    c Zhejiang Provincial Clinical Research Center for Child Health, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China;

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    d Clinical Research Center on Birth Defect Prevention and Intervention of Zhejiang Province, Hangzhou, Zhejiang 310006, China;

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    e Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang 310058, China;

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    f Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorder, Hangzhou, Zhejiang 310058, China

Funds:

This study was supported in part by the National Key R&D Program of China (2021YFC2700403 and 2018YFA0800102), and the National Natural Science Foundation of China (31871249 and 31871452)

  • Received Date: 2023-07-03
  • Revised Date: 2023-09-17
    • Available Online: 2023-09-28
    Abstract

  • Polycystic ovary syndrome (PCOS) is a highly familial and heritable endocrine disorder. Over half of the daughters born to women with PCOS may eventually develop their own PCOS-related symptoms. Progress in the treatment of PCOS is currently hindered by the complexity of its clinical manifestations and incomplete knowledge of its etiopathogenesis. Various animal models, including experimentally-induced, naturally-occurring, and spontaneously-arising ones, have been established to emulate a wide range of phenotypical and pathological traits of human PCOS. These studies have led to a paradigm shift for understanding the genetic,developmental, and evolutionary origins of this disorder. Furthermore, emerging evidence suggests that animal models are useful in evaluating state-of-the-art drugs and treatments for PCOS. This review aims to provide a comprehensive summary of recent studies of PCOS in animal models, highlighting the power of these disease models in understanding the biology of PCOS and aiding high-throughput approaches.

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