Microbiota-gut-brain axis in autism spectrum disorder

You Yu; Fangqing Zhao

doi:10.1016/j.jgg.2021.07.001

Volume 48 Issue 9

Sep. 2021

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Article Navigation > Journal of Genetics and Genomics > 2021 > 48(9): 755-762

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Microbiota-gut-brain axis in autism spectrum disorder

doi: 10.1016/j.jgg.2021.07.001

You Yu^a,
Fangqing Zhao^a,b

a. Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China;
b. University of Chinese Academy of Sciences, Beijing 100049, China

Funds:

This work was supported by grants from the Beijing Natural Science Foundation (JQ18020), the National Natural Science Foundation of China (32025009, 91951209, 31722031).

Received Date: 2021-05-10
Revised Date: 2021-06-27
Accepted Date: 2021-07-05
Publish Date: 2021-07-19

Abstract

Abstract

Extensive studies, largely during the past decade, identify the dynamic and bidirectional interaction between the bacteria resident in the intestines and their host brain along the "microbiota-gut-brain axis". This interaction modulates the development and function of the central nervous system and is implicated in neurological disorders. As a neurodevelopmental disorder, autism spectrum disorder (ASD) is considered a historically defect in the brain. With accumulating evidence showing how the microorganisms modulate neural activities, more and more research is focusing on the role of the gut microbiota in mitigating ASD symptoms and the underlying mechanisms. In this review, we describe the intricate and crucial pathways via which the gut microbiota communicates with the brain, the microbiota-gut-brain axis, and summarize the specific pathways that mediate the crosstalk of the gut microbiota to the brain in ASD.

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