Comparative study of gut microbiota from captive and confiscated-rescued wild pangolins

Chunbing Liu; Jingyang Hu; Yajiang Wu; David M. Irwin; Wu Chen; Zhigang Zhang; Li Yu

doi:10.1016/j.jgg.2021.07.009

Volume 48 Issue 9

Sep. 2021

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Article Navigation > Journal of Genetics and Genomics > 2021 > 48(9): 825-835

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Comparative study of gut microbiota from captive and confiscated-rescued wild pangolins

doi: 10.1016/j.jgg.2021.07.009

a. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China;
b. Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou 510070, China;
c. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Funds:

We thank English-native speakers Dr. John Blackwell and his colleagues for honing the English of the manuscript. The research was supported by the National Science Fund for Distinguished Young Scholars, China (31925006), the Major Science and Technology Project in Yunnan Province of China, China (202001BB050001), the Second Tibetan Plateau Scientific Expedition and Research (STEP) program, China (2019QZKK0503), and the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences.

Received Date: 2021-05-17
Revised Date: 2021-07-11
Accepted Date: 2021-07-21
Publish Date: 2021-08-05

Abstract

Abstract

Pangolins are among the most critically endangered animals due to widespread poaching and worldwide trafficking. Captive breeding is considered to be one way to protect them and increase the sizes of their populations. However, comparative studies of captive and wild pangolins in the context of gut microbiota are rare. Here, the gut microbiome of captive and confiscated-rescued wild pangolins is compared, and the effects of different periods of captivity and captivity with and without antibiotic treatment are considered. We show that different diets and periods of captivity, as well as the application of antibiotic therapy, can alter gut community composition and abundance in pangolins. Compared to wild pangolins, captive pangolins have an increased capacity for chitin and cellulose/hemicellulose degradation, fatty acid metabolism, and short-chain fatty acid synthesis, but a reduced ability to metabolize exogenous substances. In addition to increasing the ability of the gut microbiota to metabolize nutrients in captivity, captive breeding imposes some risks for survival by resulting in a greater abundance of antibiotic resistance genes and virulence factors in captive pangolins than in wild pangolins. Our study is important for the development of guidelines for pangolin conservation, including health assessment, disease prevention, and rehabilitation of wild pangolin populations.
- Pangolin,
- Gut microbiome,
- Captivity,
- Antibiotic resistance genes,
- Virulence factors

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References(82)

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